Parkinson's Disease
May 2020 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Tai Chi versus routine exercise in patients with early- or mild-stage Parkinson's disease: a retrospective cohort analysis.
Authors:Li Q, Liu J, Dai F, Dai F
Institution:Department of Neurology, Gaomi People's Hospital, Gaomi, Shandong, China.
Journal:Braz J Med Biol Res. 2020 Feb 10;53(2):e9171. doi: 10.1590/1414-431X20199171. eCollection 2020.

2:Diagnosis and Treatment of Parkinson Disease: A Review.
Authors:Armstrong MJ, Okun MS
Institution:Department of Neurology, University of Florida College of Medicine, Gainesville.
Journal:JAMA. 2020 Feb 11;323(6):548-560. doi: 10.1001/jama.2019.22360.

3:Geriatric Rehabilitation: Gait in the Elderly, Fall Prevention and Parkinson Disease.
Authors:Swanson R, Robinson KM
Institution:Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3800 Woodland Avenue, Philadelphia, PA 19104, USA. University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3800 Woodland Avenue, Philadelphia, PA 19104, USA. Electronic address: Keith.Robinson@va.gov.
Journal:Med Clin North Am. 2020 Mar;104(2):327-343. doi: 10.1016/j.mcna.2019.10.012. Epub 2019 Dec 19.

4:Inhaled levodopa for intermittent treatment of OFF episodes in patients with Parkinson's disease.
Authors:Simões RM, Castro Caldas A, Ferreira JJ
Institution:Neurology Department, Hospital Beatriz Ângelo, Loures, Portugal. Lisbon, Portugal. Lisbon, Portugal. Lisbon, Portugal.
Journal:Expert Rev Clin Pharmacol. 2020 Feb;13(2):85-101. doi: 10.1080/17512433.2020.1724535. Epub 2020 Feb 14.

5:iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Authors:Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN
Institution:Cedars-Sinai Board of Governors Regenerative Medicine Institute, Los Angeles, CA, USA. USA. USA. USA. USA. USA. USA. USA. Angeles, CA, USA. USA. USA. USA. USA. Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Journal:Nat Med. 2020 Feb;26(2):289-299. doi: 10.1038/s41591-019-0739-1. Epub 2020 Jan 27.

6:The benefits and mechanisms of exercise training for Parkinson's disease.
Authors:Feng YS, Yang SD, Tan ZX, Wang MM, Xing Y, Dong F, Zhang F
Institution:Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Queensland, Brisbane 4072, Australia; Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. University, Shijiazhuang 050051, PR China. University, Shijiazhuang 050051, PR China. University, Shijiazhuang 050051, PR China. University, Shijiazhuang 050051, PR China. University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Electronic address: ydsyzf@hebmu.edu.cn.
Journal:Life Sci. 2020 Mar 15;245:117345. doi: 10.1016/j.lfs.2020.117345. Epub 2020 Jan 22.

7:State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson's disease.
Authors:Quarracino C, Otero-Losada M, Capani F, Pérez-Lloret S
Institution:Institute of Cardiological Research, University of Buenos Aires, National Research Council, ININCA, UBA, CONICET, Buenos Aires, Argentina. Council, ININCA, UBA, CONICET, Buenos Aires, Argentina. Council, ININCA, UBA, CONICET, Buenos Aires, Argentina. Council, ININCA, UBA, CONICET, Buenos Aires, Argentina. Buenos Aires, Argentina.
Journal:Expert Opin Pharmacother. 2020 Mar;21(4):445-457. doi: 10.1080/14656566.2020.1713097. Epub 2020 Jan 20.

8:Smartphone Based Timed Up and Go Test Can Identify Postural Instability in Parkinson's Disease.
Authors:Yahalom G, Yekutieli Z, Israeli-Korn S, Elincx-Benizri S, Livneh V, Fay-Karmon T, Tchelet K, Rubel Y, Hassin-Baer S
Institution:Department of Neurology and Movement Disorders Clinic, Shaare Zedek Medical Center, Jerusalem, Israel. Israel. Israel.
Journal:Isr Med Assoc J. 2020 Jan;22(1):37-42.

9:The future of stem cell therapies for Parkinson disease.
Authors:Parmar M, Grealish S, Henchcliffe C
Institution:Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. malin.parmar@med.lu.se. Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Journal:Nat Rev Neurosci. 2020 Feb;21(2):103-115. doi: 10.1038/s41583-019-0257-7. Epub 2020 Jan 6.

10:Comparison of Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation Surgery on Parkinson Disease-Related Pain.
Authors:Gong S, Xu M, Tao Y, Jin H, Liu Y, Sun X, Wang S, Yang X, Wang Y, Yuan L, Song W
Institution:Department of Neurosurgery, The General Hospital of Northern Theater Command (The Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Electronic address: yingquntao@163.com. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China. Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China.
Journal:World Neurosurg. 2020 Mar;135:e94-e99. doi: 10.1016/j.wneu.2019.11.026. Epub 2019 Nov 13.

11:Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial.
Authors:Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A
Institution:Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Sciences, Shiraz, Iran. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Sciences, Shiraz, Iran; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: hamediaz@sums.ac.ir.
Journal:J Ethnopharmacol. 2020 Jan 30;247:112226. doi: 10.1016/j.jep.2019.112226. Epub 2019 Sep 28.

12:Effect of Repetitive Transcranial Magnetic Stimulation on Gait and Freezing of Gait in Parkinson Disease: A Systematic Review and Meta-analysis.
Authors:Xie YJ, Gao Q, He CQ, Bian R
Institution:Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China. Chengdu, Sichuan Province, People's Republic of China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China. Chengdu, Sichuan Province, People's Republic of China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China. Electronic address: hxkfhcq2015@126.com. University, Nanjing, Jiangsu Province, People's Republic of China.
Journal:Arch Phys Med Rehabil. 2020 Jan;101(1):130-140. doi: 10.1016/j.apmr.2019.07.013. Epub 2019 Aug 26.

13:Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders.
Authors:Umemoto G, Furuya H
Institution:Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Japan.
Journal:Intern Med. 2020 Jan 1;59(1):7-14. doi: 10.2169/internalmedicine.2373-18. Epub 2019 Apr 17.

14:Assessment of Motor Impairments in Early Untreated Parkinson's Disease Patients: The Wearable Electronics Impact.
Authors:Ricci M, Di Lazzaro G, Pisani A, Mercuri NB, Giannini F, Saggio G
Journal:IEEE J Biomed Health Inform. 2020 Jan;24(1):120-130. doi: 10.1109/JBHI.2019.2903627. Epub 2019 Mar 7.

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"I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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