Parkinson's Disease
September 2021 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The Effects of Yoga on Patients with Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials.
Authors:Ban M, Yue X, Dou P, Zhang P
Institution:Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Journal:Behav Neurol. 2021 Jul 5;2021:5582488. doi: 10.1155/2021/5582488. eCollection 2021.

2:Bilirubin: A Promising Therapy for Parkinson's Disease.
Authors:Jayanti S, Moretti R, Tiribelli C, Gazzin S
Institution:Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149 Trieste, Italy.
Journal:Int J Mol Sci. 2021 Jun 9;22(12):6223. doi: 10.3390/ijms22126223.

3:Progress towards therapies for disease modification in Parkinson's disease.
Authors:Vijiaratnam N, Simuni T, Bandmann O, Morris HR, Foltynie T
Institution:Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK; The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. School of Medicine, Chicago, IL, USA. Sheffield, UK. Neurology, London, UK; The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. Neurology, London, UK; The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. Electronic address: t.foltynie@ucl.ac.uk.
Journal:Lancet Neurol. 2021 Jul;20(7):559-572. doi: 10.1016/S1474-4422(21)00061-2.

4:Covid-19 Infection and Parkinsonism: Is There a Link?
Authors:Bouali-Benazzouz R, Benazzouz A
Institution:Université de Bordeaux, Institut des maladies neurodégénératives, Bordeaux, France.
Journal:Mov Disord. 2021 Aug;36(8):1737-1743. doi: 10.1002/mds.28680. Epub 2021 Jun 8.

5:The Long-Term Impact of Levodopa/Carbidopa Intestinal Gel on 'Off'-time in Patients with Advanced Parkinson's Disease: A Systematic Review.
Authors:Antonini A, Odin P, Pahwa R, Aldred J, Alobaidi A, Jalundhwala YJ, Kukreja P, Bergmann L, Inguva S, Bao Y, Chaudhuri KR
Institution:Parkinson and Movement Disorders Unit, Center for Rare Neurological Diseases (ERN-RND), Department of Neurosciences, University of Padova, Padua, Italy. Angelo.antonini@unipd.it. King's College London, and Parkinson's Foundation International Centre of Excellence, King's College Hospital, London, UK.
Journal:Adv Ther. 2021 Jun;38(6):2854-2890. doi: 10.1007/s12325-021-01747-1. Epub 2021 May 20.

6:Sleep Disorders in Parkinson Disease.
Authors:Stefani A, Högl B
Institution:Department of Neurology, Medical University of Innsbruck, Anichstr. 35, Innsbruck 6020, Austria. 6020, Austria. Electronic address: birgit.ho@i-med.ac.at.
Journal:Sleep Med Clin. 2021 Jun;16(2):323-334. doi: 10.1016/j.jsmc.2021.03.001. Epub 2021 Apr 15.

7:Non-pharmacological therapies for pain management in Parkinson's disease: A systematic review.
Authors:Qureshi AR, Jamal MK, Rahman E, Paul DA, Oghli YS, Mulaffer MT, Qureshi D, Danish MA, Rana AQ
Institution:Neurology, Parkinson's Clinic of Eastern Toronto & Movement Disorders Centre, Toronto, ON, Canada. Hamilton, ON, Canada.
Journal:Acta Neurol Scand. 2021 Aug;144(2):115-131. doi: 10.1111/ane.13435. Epub 2021 May 13.

8:Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.
Authors:Barbuti PA, Barker RA, Brundin P, Przedborski S, Papa SM, Kalia LV, Mochizuki H
Institution:Departments of Neurology, Pathology and Cell Biology, and Neuroscience, Columbia University, New York, New York, USA. University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom. Science, Grand Rapids, Michigan, USA. University, New York, New York, USA. University School of Medicine, Atlanta, Georgia, USA. Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Journal:Mov Disord. 2021 Aug;36(8):1772-1780. doi: 10.1002/mds.28628. Epub 2021 May 8.

9:Challenges in the diagnosis of Parkinson's disease.
Authors:Tolosa E, Garrido A, Scholz SW, Poewe W
Institution:Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. Electronic address: eduardtolosa@gmail.com. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Journal:Lancet Neurol. 2021 May;20(5):385-397. doi: 10.1016/S1474-4422(21)00030-2.

10:New pharmacological and neuromodulation approaches for impulsive-compulsive behaviors in Parkinson's disease.
Authors:Grassi G, Albani G, Terenzi F, Razzolini L, Ramat S
Institution:Brain Center Firenze, Viale Belfiore 36, 5014, Florence, Italy. giacomograssimd@gmail.com.
Journal:Neurol Sci. 2021 Jul;42(7):2673-2682. doi: 10.1007/s10072-021-05237-8. Epub 2021 Apr 14.

11:'Striving for normality' when coping with Parkinson's disease in everyday life: A metasynthesis.
Authors:Haahr A, Groos H, Sørensen D
Institution:Research Center for Health and Welfare Technology, Programme for Rehabilitation, VIA University College, Hedeager 2, 8200 Aarhus, Denmark; Department of Public Health, Research Unit of Nursing and Health Care, Aarhus University, Aarhus, Denmark. Electronic address: anih@via.dk. University College, Hedeager 2, 8200 Aarhus, Denmark; Present affiliation: Student at Master of Science in Public Health, Fulda University of Applied Sciences, Leipziger Str. 123, 36037 Fulda, Germany. University College, Hedeager 2, 8200 Aarhus, Denmark. Electronic address: dsor@via.dk.
Journal:Int J Nurs Stud. 2021 Jun;118:103923. doi: 10.1016/j.ijnurstu.2021.103923. Epub 2021 Mar 4.

12:Is Chelation Therapy a Potential Treatment for Parkinson's Disease?
Authors:Ward RJ, Dexter DT, Martin-Bastida A, Crichton RR
Institution:Centre for Neurodegeneration and Neuroinflammation, Division of Brain Sciences, Department of Medicine, Imperial College, London W12 0NN, UK. Faculty of Science, Universite de Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
Journal:Int J Mol Sci. 2021 Mar 24;22(7):3338. doi: 10.3390/ijms22073338.

13:Current Developments in Cell Replacement Therapy for Parkinson's Disease.
Authors:Guo X, Tang L, Tang X
Institution:Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: txq6633@csu.edu.cn.
Journal:Neuroscience. 2021 May 21;463:370-382. doi: 10.1016/j.neuroscience.2021.03.022. Epub 2021 Mar 26.

14:The Role of Genetic Testing for Parkinson's Disease.
Authors:Cook L, Schulze J, Naito A, Alcalay RN
Institution:Department of Medical and Molecular Genetics/Hereditary Genomics Division, Indiana University School of Medicine, 410 West 10th Street, Indianapolis, IN, 46202-3002, USA. lpcook@iu.edu. Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Journal:Curr Neurol Neurosci Rep. 2021 Mar 8;21(4):17. doi: 10.1007/s11910-021-01100-7.

15:Clinical features associated with drooling in Parkinson's disease.
Authors:Nascimento D
Institution:Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, Rua da Junqueira n°126, 1349-019, Lisbon, Portugal. tfdavidnascimento@gmail.com.
Journal:Neurol Sci. 2021 Mar;42(3):895-903. doi: 10.1007/s10072-020-05005-0. Epub 2021 Jan 14.

16:Nanoparticles for drug delivery in Parkinson's disease.
Authors:Baskin J, Jeon JE, Lewis SJG
Institution:Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia. jonathan.baskin@sydney.edu.au.
Journal:J Neurol. 2021 May;268(5):1981-1994. doi: 10.1007/s00415-020-10291-x. Epub 2020 Nov 3.

17:Chronic pain in Parkinson's disease: Clinical and pathophysiological aspects.
Authors:Marques A, Brefel-Courbon C
Institution:Université Clermont Auvergne, EA7280, NS-Park/FCRIN Network, Clermont-Ferrand University Hospital, Neurology Department, Clermont-Ferrand, France. Electronic address: ar_marques@chu-clermontferrand.fr. Clinique CIC1436, NS-Park/FCRIN Network, UMR ToNIC 1214, University Hospital of Toulouse, Inserm, University of Toulouse 3, Toulouse, France.
Journal:Rev Neurol (Paris). 2021 Apr;177(4):394-399. doi: 10.1016/j.neurol.2020.06.015. Epub 2020 Oct 2.

18:Management of Parkinson's disease and other movement disorders in women of childbearing age: Part 2.
Authors:García-Ramos R, Santos-García D, Alonso-Cánovas A, Álvarez-Sauco M, Ares B, Ávila A, Caballol N, Carrillo F, Escamilla Sevilla F, Freire E, Gómez Esteban JC, Legarda I, López Manzanares L, López Valdés E, Martínez-Torres I, Mata M, Pareés I, Pascual-Sedano B, Martínez Castrillo JC, Mir P
Institution:Instituto de Investigación Sanitaria San Carlos (IdISCC), Hospital Clínico San Carlos, Madrid, España. Electronic address: garciaramosg@gmail.com. España. Llobregat, Barcelona, España; Consorci Sanitari Integral, Hospital Sant Joan Despí Moisés Broggi, Sant Joan Despí, Barcelona, España. Barcelona, España. Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, España; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, España. Nieves, Granada, España. Elche, Elche, Alicante, España. Carlos, Madrid, España. Madrid, España. Universitat Oberta de Catalunya (UOC), Barcelona, España; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, España. Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, España; Hospital Rúber Internacional, Madrid, España.
Journal:Neurologia (Engl Ed). 2021 Mar;36(2):159-168. doi: 10.1016/j.nrl.2020.05.012. Epub 2020 Sep 24.

19:Image Guidance in Deep Brain Stimulation Surgery to Treat Parkinson's Disease: A Comprehensive Review.
Authors:Xiao Y, Lau JC, Hemachandra D, Gilmore G, Khan AR, Peters TM
Journal:IEEE Trans Biomed Eng. 2021 Mar;68(3):1024-1033. doi: 10.1109/TBME.2020.3006765. Epub 2021 Feb 18.

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What Our Customers Are Saying...

"I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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"I found your Guidebook on Parkinson's to be very informative for me, the patient, and for my husband. I am in the process of changing my medication and the book explained more to me than the doctor attempted to. I am now more aware of what to expect. It also offered valuable advice for the caregiver. Thank you."
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