| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Punin C, Barzallo B, Clotet R, Bermeo A, Bravo M, Bermeo JP, Llumiguano C |
| Institution: | Telecommunications Research Group, Universidad Politecnica Salesiana, Cuenca 010105, Ecuador. bpunin@ups.edu.ec. 010105, Ecuador. bbarzallo@ups.edu.ec. Venezuela. clotet@usb.ve. 010105, Ecuador. abermeo@ups.edu.ec. 010105, Ecuador. mbravog@ups.edu.ec. 010105, Ecuador. jbermeo@ups.edu.ec. carlos.llumiguano@yahoo.com. | | Journal: | Sensors (Basel). 2019 Feb 12;19(3). pii: s19030737. doi: 10.3390/s19030737. |
| Authors: | Reich SG, Savitt JM |
| Institution: | Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA. Electronic address: sreich@som.umaryland.edu. | | Journal: | Med Clin North Am. 2019 Mar;103(2):337-350. doi: 10.1016/j.mcna.2018.10.014. Epub 2018 Dec 3. |
| Authors: | Verschuur CVM, Suwijn SR, Boel JA, Post B, Bloem BR, van Hilten JJ, van Laar T, Tissingh G, Munts AG, Deuschl G, Lang AE, Dijkgraaf MGW, de Haan RJ, de Bie RMA |
| Institution: | From the Department of Neurology, Amsterdam Neuroscience (C.V.M.V., S.R.S., J.A.B., R.M.A.B.), Clinical Epidemiology, Biostatistics, and Bioinformatics (M.G.W.D.), and the Clinical Research Unit (R.J.H.), Amsterdam UMC, University of Amsterdam, AMC, Amsterdam, the Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen (B.P., B.R.B.), the Department of Neurology, Leiden University Medical Center, Leiden (J.J.H.), the Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen (T.L.), the Department of Neurology, Zuyderland Medical Center, Heerlen (G.T.), and the Department of Neurology, Spaarne Gasthuis, Haarlem (A.G.M.) - all in the Netherlands; the Department of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany (G.D.); and the Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University of Toronto, Toronto (A.E.L.). | | Journal: | N Engl J Med. 2019 Jan 24;380(4):315-324. doi: 10.1056/NEJMoa1809983. |
| Authors: | Wlodarek D |
| Institution: | Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159c Nowoursynowska Str., 02-776 Warsaw, Poland. dariusz_wlodarek@sggw.pl. | | Journal: | Nutrients. 2019 Jan 15;11(1). pii: nu11010169. doi: 10.3390/nu11010169. |
| Authors: | Yeo S, van den Noort M, Bosch P, Lim S |
| Institution: | College of Korean Medicine, Sang Ji University, Wonju.; Department of Meridian and Acupoint, College of Korean Medicine and Research Group of Pain and Neuroscience, WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Nijmegen, The Netherlands. | | Journal: | Medicine (Baltimore). 2018 Dec;97(50):e13434. doi: 10.1097/MD.0000000000013434. |
| Authors: | Stocchi F, Vacca L, Stirpe P, Torti M |
| Institution: | a Departement of Neurology , University and Institute for Research and Medical Care, San Raffaele Rome , Roma , Italy. Milan , Italy. Care, San Raffaele Rome , Roma , Italy. Care, San Raffaele Rome , Roma , Italy. Raffaele Cassino , Cassino (FR) , Italy. | | Journal: | Expert Opin Drug Metab Toxicol. 2018 Dec;14(12):1189-1195. doi: 10.1080/17425255.2018.1550483. Epub 2018 Dec 2. |
| Authors: | Dragasevic-Miskovic N, Petrovic I, Stankovic I, Kostic VS |
| Institution: | a Neurology Clinic, CCS, School of Medicine , Universtiy of Belgrade , Belgrade , Serbia. Serbia. Serbia. Serbia. | | Journal: | Expert Opin Pharmacother. 2019 Feb;20(2):219-230. doi: 10.1080/14656566.2018.1543407. Epub 2018 Nov 9. |
| Authors: | Dalla Bella S |
| Institution: | International Laboratory for Brain, Music, and Sound Research (BRAMS), Montreal, Canada; Department of Psychology, University of Montreal, Montreal, Canada; Centre for Research on Brain, Language and Music (CRBLM), Montreal, Canada. Electronic address: simone.dalla.bella@umontreal.ca. | | Journal: | Neurophysiol Clin. 2018 Dec;48(6):377-386. doi: 10.1016/j.neucli.2018.10.067. Epub 2018 Nov 3. |
| Authors: | Warner CB, Ottman AA, Brown JN |
| Institution: | From the Geriatric Research, Education, and Clinical Center and. | | Journal: | J Clin Psychopharmacol. 2018 Dec;38(6):627-631. doi: 10.1097/JCP.0000000000000963. |
| Authors: | Fabbri M, Rosa MM, Ferreira JJ |
| Institution: | Instituto de Medicina Molecular, Lisbon, Portugal. Italy. Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. Centro Hospitalar Lisboa Norte, Lisbon, Portugal. Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. joaquimjferreira@gmail.com. joaquimjferreira@gmail.com. | | Journal: | Drugs Aging. 2018 Dec;35(12):1041-1054. doi: 10.1007/s40266-018-0599-2. |
| Authors: | Patel N, LeWitt P, Neikrug AB, Kesslak P, Coate B, Ancoli-Israel S |
| Institution: | Parkinson's Disease and Movement Disorders Program, Henry Ford Hospital, West Bloomfield, MI. Bloomfield, MI. Irvine. Jolla, CA. | | Journal: | Clin Neuropharmacol. 2018 Nov/Dec;41(6):210-215. doi: 10.1097/WNF.0000000000000307. |
| Authors: | Lin HY, Hasegawa H, Mundil N, Samuel M, Ashkan K |
| Institution: | Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. Health Partners, London, United Kingdom; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. Electronic address: h.hasegawa@nhs.net. Health Partners, London, United Kingdom. Excellence, King's College Hospital, King's Health Partners, London, United Kingdom. Health Partners, London, United Kingdom; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. | | Journal: | World Neurosurg. 2019 Jan;121:e654-e660. doi: 10.1016/j.wneu.2018.09.181. Epub 2018 Oct 4. |
| Authors: | Intzandt B, Beck EN, Silveira CRA |
| Institution: | PERFORM Centre, Concordia University, 7200 rue Sherbrooke O, Montreal, H4B 1R6, Canada. Electronic address: brittany.intzandt@mail.concordia.ca. Dublin, 2, Ireland. Electronic address: becke@tcd.ie. Electronic address: carolina.silveira@sjhc.london.on.ca. | | Journal: | Neurosci Biobehav Rev. 2018 Dec;95:136-169. doi: 10.1016/j.neubiorev.2018.09.018. Epub 2018 Oct 3. |
| Authors: | Torti M, Vacca L, Stocchi F |
| Institution: | a Center for Parkinson's Disease , IRCCS San Raffaele Pisana , Rome , Italy. | | Journal: | Expert Opin Pharmacother. 2018 Nov;19(16):1821-1828. doi: 10.1080/14656566.2018.1524876. Epub 2018 Oct 11. |
| Authors: | Thomas I, Memedi M, Westin J, Nyholm D |
| Institution: | Department of Micro-data Analysis, Dalarna University, Falun, Sweden. | | Journal: | Acta Neurol Scand. 2019 Jan;139(1):70-75. doi: 10.1111/ane.13020. Epub 2018 Sep 24. |
| Authors: | Puy L, Tir M, Lefranc M, Yaiche H, Godefroy O, Krystkowiak P |
| Institution: | Department of Neurology and Laboratory of Functional Neurosciences, Amiens University Medical Center, Amiens, France. Electronic address: laurent.puy@hotmail.fr.; Department of Neurosurgery, Amiens University Hospital, Amiens, France. | | Journal: | World Neurosurg. 2018 Nov;119:63-65. doi: 10.1016/j.wneu.2018.07.197. Epub 2018 Jul 31. |
| Authors: | Niu J, Xie J, Guo K, Zhang X, Xia F, Zhao X, Song L, Zhuge D, Li X, Zhao Y, Huang Z |
| Institution: | a School of Pharmaceutical Sciences & Center for Structural Biology , Wenzhou Medical University , Wenzhou , Zhejiang , China. | | Journal: | Drug Deliv. 2018 Nov;25(1):1560-1569. doi: 10.1080/10717544.2018.1482972. |
| Authors: | Torny F, Videaud H, Chatainier P, Tarrade C, Meissner WG, Couratier P |
| Institution: | Centre expert Parkinson, service de neurologie, CHU de Limoges, 2, avenue Martin-Luther-King, 87025 Limoges, France. Electronic address: centre.parkinson@chu-limoges.fr.; Centre expert Parkinson, IMNc, CHU de Bordeaux, 33000 Bordeaux cedex, France. | | Journal: | Rev Neurol (Paris). 2018 Dec;174(10):711-715. doi: 10.1016/j.neurol.2018.01.372. Epub 2018 Jul 20. |
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What Our Customers Are Saying... "I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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Russelsheim, Germany
"I found your Guidebook on Parkinson's to be very informative for me, the patient, and for my husband. I am in the process of changing my medication and the book explained more to me than the doctor attempted to. I am now more aware of what to expect. It also offered valuable advice for the caregiver. Thank you."
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Palm Spring, California
"The Medifocus Guide to Parkinson's Disease was useful, informative, and allowed me to grasp the current fundamentals of treatment. I have recommended it to two of my ex-patients whom I know will find it readable and helpful to their needs."
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Research Triangle Park, NC
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