Parkinson's Disease
May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Tai Chi versus routine exercise in patients with early- or mild-stage Parkinson's disease: a retrospective cohort analysis.
Authors:Li Q, Liu J, Dai F, Dai F
Institution:Department of Neurology, Gaomi People's Hospital, Gaomi, Shandong, China. Department of Neurosurgery, Gaomi People's Hospital, Gaomi, Shandong, China.
Journal:Braz J Med Biol Res. 2020 Feb 10;53(2):e9171. doi: 10.1590/1414-431X20199171. eCollection 2020.

2:Diagnosis and Treatment of Parkinson Disease: A Review.
Authors:Armstrong MJ, Okun MS
Institution:Department of Neurology, University of Florida College of Medicine, Gainesville.
Journal:JAMA. 2020 Feb 11;323(6):548-560. doi: 10.1001/jama.2019.22360.

3:Geriatric Rehabilitation: Gait in the Elderly, Fall Prevention and Parkinson Disease.
Authors:Swanson R, Robinson KM
Institution:Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz Veterans Affairs Medical Center, 3800 Wo
Journal:Med Clin North Am. 2020 Mar;104(2):327-343. doi: 10.1016/j.mcna.2019.10.012. Epub 2019 Dec 19.

4:Inhaled levodopa for intermittent treatment of OFF episodes in patients with Parkinson's disease.
Authors:Simões RM, Castro Caldas A, Ferreira JJ
Institution:Neurology Department, Hospital Beatriz Angelo, Loures, Portugal. CNS-Campus Neurologico Senior, Torres Vedras, Portugal.
Journal:Expert Rev Clin Pharmacol. 2020 Feb;13(2):85-101. doi: 10.1080/17512433.2020.1724535. Epub 2020 Feb 14.

5:The benefits and mechanisms of exercise training for Parkinson's disease.
Authors:Feng YS, Yang SD, Tan ZX, Wang MM, Xing Y, Dong F, Zhang F
Institution:Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebe
Journal:Life Sci. 2020 Mar 15;245:117345. doi: 10.1016/j.lfs.2020.117345. Epub 2020 Jan 22.

6:State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson's disease.
Authors:Quarracino C, Otero-Losada M, Capani F, Pérez-Lloret S
Institution:Institute of Cardiological Research, University of Buenos Aires, National Research Council, ININCA, UBA, CONICET, Buenos Aires, Argentina.
Journal:Expert Opin Pharmacother. 2020 Mar;21(4):445-457. doi: 10.1080/14656566.2020.1713097. Epub 2020 Jan 20.

7:Smartphone Based Timed Up and Go Test Can Identify Postural Instability in Parkinson's Disease.
Authors:Yahalom G, Yekutieli Z, Israeli-Korn S, Elincx-Benizri S, Livneh V, Fay-Karmon T, Tchelet K, Rubel Y, Hassin-Baer S
Institution:Department of Neurology and Movement Disorders Clinic, Shaare Zedek Medical Center, Jerusalem, Israel. Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
Journal:Isr Med Assoc J. 2020 Jan;22(1):37-42.

8:The future of stem cell therapies for Parkinson disease.
Authors:Parmar M, Grealish S, Henchcliffe C
Institution:Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Department of Neurology, Weill Cornell Medical College, New York, NY, USA.
Journal:Nat Rev Neurosci. 2020 Feb;21(2):103-115. doi: 10.1038/s41583-019-0257-7. Epub 2020 Jan 6.

9:Comparison of Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation Surgery on Parkinson Disease-Related Pain.
Authors:Gong S, Xu M, Tao Y, Jin H, Liu Y, Sun X, Wang S, Yang X, Wang Y, Yuan L, Song W
Institution:Department of Neurosurgery, The General Hospital of Northern Theater Command (The Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, Shenyang, China.
Journal:World Neurosurg. 2020 Mar;135:e94-e99. doi: 10.1016/j.wneu.2019.11.026. Epub 2019 Nov 13.

10:Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial.
Authors:Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A
Institution:Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. E
Journal:J Ethnopharmacol. 2020 Jan 30;247:112226. doi: 10.1016/j.jep.2019.112226. Epub 2019 Sep 28.

11:Effect of Repetitive Transcranial Magnetic Stimulation on Gait and Freezing of Gait in Parkinson Disease: A Systematic Review and Meta-analysis.
Authors:Xie YJ, Gao Q, He CQ, Bian R
Institution:Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China. Department of Rehabilitation, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
Journal:Arch Phys Med Rehabil. 2020 Jan;101(1):130-140. doi: 10.1016/j.apmr.2019.07.013. Epub 2019 Aug 26.

12:Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders.
Authors:Umemoto G, Furuya H
Institution:Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Japan. Department of Neurology, Kochi Medical School, Kochi University, Japan.
Journal:Intern Med. 2020 Jan 1;59(1):7-14. doi: 10.2169/internalmedicine.2373-18. Epub 2019 Apr 17.

13:Assessment of Motor Impairments in Early Untreated Parkinson's Disease Patients: The Wearable Electronics Impact.
Authors:Ricci M, Di Lazzaro G, Pisani A, Mercuri NB, Giannini F, Saggio G
Journal:IEEE J Biomed Health Inform. 2020 Jan;24(1):120-130. doi: 10.1109/JBHI.2019.2903627. Epub 2019 Mar 7.

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