Parkinson's Disease
January 2019 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Nighttime Sleep and Daytime Sleepiness Improved With Pimavanserin During Treatment of Parkinson's Disease Psychosis.
Authors:Patel N, LeWitt P, Neikrug AB, Kesslak P, Coate B, Ancoli-Israel S
Institution:Parkinson's Disease and Movement Disorders Program, Henry Ford Hospital, West Bloomfield, MI. Bloomfield, MI. Irvine. Jolla, CA.
Journal:Clin Neuropharmacol. 2018 Nov/Dec;41(6):210-215. doi: 10.1097/WNF.0000000000000307.

2:Istradefylline for the treatment of Parkinson's disease: is it a promising strategy?
Authors:Torti M, Vacca L, Stocchi F
Institution:a Center for Parkinson's Disease , IRCCS San Raffaele Pisana , Rome , Italy.
Journal:Expert Opin Pharmacother. 2018 Nov;19(16):1821-1828. doi: 10.1080/14656566.2018.1524876. Epub 2018 Oct 11.

3:Speech disorders in Parkinson's disease: pathophysiology, medical management and surgical approaches.
Authors:Dashtipour K, Tafreshi A, Lee J, Crawley B
Institution:Department of Neurology, Loma Linda University School of Medicine, Loma Linda, CA, USA. CA, USA. CA, USA. Linda, CA, USA.
Journal:Neurodegener Dis Manag. 2018 Oct;8(5):337-348. doi: 10.2217/nmt-2018-0021. Epub 2018 Sep 18.

4:The long-term efficacy of STN vs GPi deep brain stimulation for Parkinson disease: A meta-analysis.
Authors:Peng L, Fu J, Ming Y, Zeng S, He H, Chen L
Institution:Department of Neurosurgery. Luzhou, China.
Journal:Medicine (Baltimore). 2018 Aug;97(35):e12153. doi: 10.1097/MD.0000000000012153.

5:Regenerative Therapies for Parkinson's Disease: An Update.
Authors:Stoker TB, Barker RA
Institution:John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK. tbs26@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. tbs26@cam.ac.uk.
Journal:BioDrugs. 2018 Aug;32(4):357-366. doi: 10.1007/s40259-018-0294-1.

6:Decisions about deep brain stimulation therapy in Parkinson's disease.
Authors:Brandao P, Grippe TC, Modesto LC, Ferreira AGF, Silva FMD, Pereira FF, Lobo ME, Allam N, Freitas TDS, Munhoz RP
Institution:Universidade de Brasilia, Laboratorio de Neurociencia e Comportamento, Brasilia DF, Brasil. Brasil. Brasil. DF, Brasil. Brasil. University Health Network, Toronto, Canada.
Journal:Arq Neuropsiquiatr. 2018 Jun;76(6):411-420. doi: 10.1590/0004-282X20180048.

7:Impulse control and related disorders in Parkinson's disease.
Authors:Vargas AP, Cardoso FEC
Institution:Rede SARAH de Hospitais de Reabilitacao, Departamento de Neurologia, Belo Horizonte MG, Brasil. Departamento de Clinica Medica, Servico de Neurologia, Belo Horizonte MG, Brasil.
Journal:Arq Neuropsiquiatr. 2018 Jun;76(6):399-410. doi: 10.1590/0004-282X20180052.

8:Therapy With Mesenchymal Stem Cells in Parkinson Disease: History and Perspectives.
Authors:Mendes Filho D, Ribeiro PDC, Oliveira LF, de Paula DRM, Capuano V, de Assuncao TSF, da Silva VJD
Institution:Departments of Physiology, Biological and Natural Sciences Institute. Medical School, Sao Jose do Rio Preto, SP. (INCT-REGENERA-CNPq), Rio de Janeiro, RJ. Federal University, Uberaba. Belo Horizonte, MG, Brazil. Federal University, Uberaba.
Journal:Neurologist. 2018 Jul;23(4):141-147. doi: 10.1097/NRL.0000000000000188.

9:Pharmacological interventions for anxiety in Parkinson's disease sufferers.
Authors:Sawada H, Umemura A, Kohsaka M, Tomita S, Park K, Oeda T, Yamamoto K
Institution:a Department of Neurology & Clinical Research Center , Utano National Hospital , Kyoto , Japan. Kyoto , Japan. Kyoto , Japan. Kyoto , Japan. Kyoto , Japan. Kyoto , Japan. Kyoto , Japan.
Journal:Expert Opin Pharmacother. 2018 Jul;19(10):1071-1076. doi: 10.1080/14656566.2018.1485650. Epub 2018 Jun 25.

10:Long-term management of Parkinson's disease using levodopa combinations.
Authors:Muller T, Mohr JD
Institution:a Department of Neurology , St. Joseph Hospital Berlin-Weissensee , Berlin , Germany. Germany.
Journal:Expert Opin Pharmacother. 2018 Jun;19(9):1003-1011. doi: 10.1080/14656566.2018.1484108. Epub 2018 Jun 18.

11:Flavonoids as Therapeutic Agents in Alzheimer's and Parkinson's Diseases: A Systematic Review of Preclinical Evidences.
Authors:de Andrade Teles RB, Diniz TC, Costa Pinto TC, de Oliveira Junior RG, Gama E Silva M, de Lavor EM, Fernandes AWC, de Oliveira AP, de Almeida Ribeiro FPR, da Silva AAM, Cavalcante TCF, Quintans Junior LJ, da Silva Almeida JRG
Institution:Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil. 44036-900 Feira de Santana, BA, Brazil. University of Pernambuco, 50740-521 Recife, PE, Brazil.
Journal:Oxid Med Cell Longev. 2018 May 10;2018:7043213. doi: 10.1155/2018/7043213. eCollection 2018.

12:Neurorehabilitation in Parkinson's Disease: A Critical Review of Cognitive Rehabilitation Effects on Cognition and Brain.
Authors:Diez-Cirarda M, Ibarretxe-Bilbao N, Pena J, Ojeda N
Institution:Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain.
Journal:Neural Plast. 2018 May 6;2018:2651918. doi: 10.1155/2018/2651918. eCollection 2018.

13:Safinamide for Parkinson's disease.
Authors:
Journal:Drug Ther Bull. 2018 May;56(5):54-57. doi: 10.1136/dtb.2018.5.0623.

14:Cardiac abnormalities in Parkinson's disease and Parkinsonism.
Authors:Scorza FA, Fiorini AC, Scorza CA, Finsterer J
Institution:Disciplina de Neurociencia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, Brazil. Electronic address: scorza@unifesp.br. Catolica de Sao Paulo (PUC-SP), Brazil; Departamento de Fonoaudiologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, Brazil. Electronic address: acfiorini@pucsp.br. Sao Paulo (EPM/UNIFESP), Sao Paulo, Brazil. fifigs1@yahoo.de.
Journal:J Clin Neurosci. 2018 Jul;53:1-5. doi: 10.1016/j.jocn.2018.04.031. Epub 2018 Apr 26.

15:Subjective and psychological well-being in Parkinson's Disease: A systematic review.
Authors:Vescovelli F, Sarti D, Ruini C
Institution:Department of Psychology, University of Bologna, Bologna, Italy.
Journal:Acta Neurol Scand. 2018 Jul;138(1):12-23. doi: 10.1111/ane.12946. Epub 2018 Apr 25.

16:Herbal Prescriptions and Medicinal Herbs for Parkinson-Related Rigidity in Korean Medicine: Identification of Candidates Using Text Mining.
Authors:Park SH, Hwang MS, Park HJ, Shin HK, Baek JU, Choi BT
Institution:1 Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.; 2 Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University , Yangsan, Republic of Korea.
Journal:J Altern Complement Med. 2018 Jul;24(7):733-740. doi: 10.1089/acm.2017.0387. Epub 2018 Mar 27.

17:The role of extended-release amantadine for the treatment of dyskinesia in Parkinson's disease patients.
Authors:Elkurd MT, Bahroo LB, Pahwa R
Institution:Department of Neurology, Medstar Georgetown University Hospital, Georgetown, Washington DC, USA. Washington DC, USA.
Journal:Neurodegener Dis Manag. 2018 Apr;8(2):73-80. doi: 10.2217/nmt-2018-0001. Epub 2018 Mar 22.

18:Early Life Stress, Depression And Parkinson's Disease: A New Approach.
Authors:Dalle E, Mabandla MV
Institution:School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa. dumessherve@yahoo.fr.
Journal:Mol Brain. 2018 Mar 19;11(1):18. doi: 10.1186/s13041-018-0356-9.

19:Genetic risk factors in Parkinson's disease.
Authors:Billingsley KJ, Bandres-Ciga S, Saez-Atienzar S, Singleton AB
Institution:Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD, 20892, USA. singleta@mail.nih.gov.; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3BX, Liverpool, UK.
Journal:Cell Tissue Res. 2018 Jul;373(1):9-20. doi: 10.1007/s00441-018-2817-y. Epub 2018 Mar 13.

20:Pharmacological interventions for psychosis in Parkinson's disease patients.
Authors:Friedman JH
Institution:a Movement Disorders Program , Butler Hospital , Providence , RI , USA. Providence , RI , USA.
Journal:Expert Opin Pharmacother. 2018 Apr;19(5):499-505. doi: 10.1080/14656566.2018.1445721. Epub 2018 Mar 1.

21:Effects of physical exercise programs on cognitive function in Parkinson's disease patients: A systematic review of randomized controlled trials of the last 10 years.
Authors:da Silva FC, Iop RDR, de Oliveira LC, Boll AM, de Alvarenga JGS, Gutierres Filho PJB, de Melo LMAB, Xavier AJ, da Silva R
Institution:University of State of Santa Catarina, Center for Health Sciences and Sports, Adapted Physical Activity Laboratory, Florianopolis, Santa Catarina, Brazil.; University of Brasilia, Faculty of Physical Education, Brasilia, Brazil.; University of Southern Santa Catarina, Medicine Course, Florianopolis, Santa Catarina, Brazil.
Journal:PLoS One. 2018 Feb 27;13(2):e0193113. doi: 10.1371/journal.pone.0193113. eCollection 2018.

22:The potential role of herbal products in the treatment of Parkinson's disease.
Authors:Amro MS, Teoh SL, Norzana AG, Srijit D
Institution:Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia. Lumpur, Malaysia. Lumpur, Malaysia. Lumpur, Malaysia.
Journal:Clin Ter. 2018 Jan-Feb;169(1):e23-e33. doi: 10.7417/T.2018.2050.

23:The launch of opicapone for Parkinson's disease: negatives versus positives.
Authors:Castro Caldas A, Teodoro T, Ferreira JJ
Institution:a Neurology Service, Department of Neurosciences , Hospital de Santa Maria , Lisbon , Portugal. Portugal. University Hospitals NHS Foundation Trust , London , United Kingdom.
Journal:Expert Opin Drug Saf. 2018 Mar;17(3):331-337. doi: 10.1080/14740338.2018.1433659.

24:Beneficial Effects of Flavonoids Against Parkinson's Disease.
Authors:Jung UJ, Kim SR
Institution:1 Department of Food Science and Nutrition, Pukyong National University , Busan, Korea. Life Science and Biotechnology, Kyungpook National University , Daegu, Korea. Korea.
Journal:J Med Food. 2018 May;21(5):421-432. doi: 10.1089/jmf.2017.4078. Epub 2018 Feb 7.

25:Fatigue in Parkinson's disease: concepts and clinical approach.
Authors:Nassif DV, Pereira JS
Institution:Department of Neurology, Pedro Ernesto University Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Rio de Janeiro, Rio de Janeiro, Brazil.
Journal:Psychogeriatrics. 2018 Mar;18(2):143-150. doi: 10.1111/psyg.12302. Epub 2018 Feb 6.

26:Constipation in Parkinson's Disease: a Nuisance or Nuanced Answer to the Pathophysiological Puzzle?
Authors:Sharma A, Kurek J, Morgan JC, Wakade C, Rao SSC
Institution:Division of Gastroenterology/Hepatology, Medical College of Georgia, Augusta University Medical Center, 1120 15th Street, AD-2226, Augusta, GA, 30912, USA. amosharma@augusta.edu.; Parkinson's Foundation Center of Excellence, Movement Disorders Program, Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Department of Physical Therapy, College of Allied Health Sciences, Augusta University & Charlie Norwood VAMC, Augusta, GA, USA.
Journal:Curr Gastroenterol Rep. 2018 Jan 19;20(1):1. doi: 10.1007/s11894-018-0609-x.

27:Safinamide: a new hope for Parkinson's disease?
Authors:Teixeira FG, Gago MF, Marques P, Moreira PS, Magalhaes R, Sousa N, Salgado AJ
Institution:Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. Electronic address: fabioteixeira@med.uminho.pt.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal; Neurology Department, Hospital da Senhora da Oliveira, EPE, Guimaraes, Portugal.
Journal:Drug Discov Today. 2018 Mar;23(3):736-744. doi: 10.1016/j.drudis.2018.01.033. Epub 2018 Jan 12.

28:Gene Therapy for Parkinson's Disease.
Authors:Sudhakar V, Richardson RM
Journal:Prog Neurol Surg. 2018;33:253-264. doi: 10.1159/000481109. Epub 2018 Jan 12.

29:Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for Parkinson's Disease.
Authors:Lee PS, Crammond DJ, Richardson RM
Journal:Prog Neurol Surg. 2018;33:207-221. doi: 10.1159/000481105. Epub 2018 Jan 12.

30:Radiosurgical Pallidotomy for Parkinson's Disease.
Authors:Cahan LD, Young RF, Li F
Journal:Prog Neurol Surg. 2018;33:149-157. doi: 10.1159/000481083. Epub 2018 Jan 12.

31:Towards stem cell based therapies for Parkinson's disease.
Authors:Parmar M
Institution:Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, BMC A11, S-221 84 Lund, Sweden malin.parmar@med.lu.se.
Journal:Development. 2018 Jan 8;145(1). pii: 145/1/dev156117. doi: 10.1242/dev.156117.

32:Palliative care for Parkinson's disease.
Authors:Ng JSC
Institution:Palliative medicine physician, Haven of Hope Hospital, Hong Kong, China. ngscj@ha.org.hk.
Journal:Ann Palliat Med. 2018 Jul;7(3):296-303. doi: 10.21037/apm.2017.12.02. Epub 2018 Jan 4.

33:Neurotrophic factors hold promise for the future of Parkinson's disease treatment: is there a light at the end of the tunnel?
Authors:Nasrolahi A, Mahmoudi J, Akbarzadeh A, Karimipour M, Sadigh-Eteghad S, Salehi R, Farhoudi M
Institution:Molecular Medicine Department, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 51656-87386, Iran. 51666-14756, Iran. 51666-14756, Iran. Tabriz University of Medical Sciences, Tabriz 51656-87386, Iran. of Medical Sciences, Tabriz 51656-87386, Iran. Sciences, Tabriz 51656-87386, Iran. 51666-14756, Iran. Tabriz University of Medical Sciences, Tabriz 51656-87386, Iran. 51666-14756, Iran. of Medical Sciences, Tabriz 51656-87386, Iran.
Journal:Rev Neurosci. 2018 Jul 26;29(5):475-489. doi: 10.1515/revneuro-2017-0040.

34:Stem Cell Transplantation and Physical Exercise in Parkinson's Disease, a Literature Review of Human and Animal Studies.
Authors:Hurtado JDC, Sanchez JPB, Nunes RB, de Oliveira AA
Institution:Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. ft.jaisonhurtado@gmail.com. Porto Alegre, Rio Grande Do Sul, CEP 90.050-170, Brazil. ft.jaisonhurtado@gmail.com.
Journal:Stem Cell Rev. 2018 Apr;14(2):166-176. doi: 10.1007/s12015-017-9798-1.

35:Efficacy and safety of perampanel in Parkinson's disease. A systematic review with meta-analysis.
Authors:Lattanzi S, Grillo E, Brigo F, Silvestrini M
Institution:Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Via Conca 71, 60020, Ancona, Italy. alfierelattanzisimona@gmail.com. Verona, Verona, Italy. Polytechnic University, Via Conca 71, 60020, Ancona, Italy.
Journal:J Neurol. 2018 Apr;265(4):733-740. doi: 10.1007/s00415-017-8681-y. Epub 2017 Nov 20.

36:Pimavanserin: novel pharmacotherapy for Parkinson's disease psychosis.
Authors:Sahli ZT, Tarazi FI
Institution:a Department of Psychiatry and Neuroscience Program , Harvard Medical School, McLean Hospital , Belmont , MA , USA. McLean Hospital , Belmont , MA , USA.
Journal:Expert Opin Drug Discov. 2018 Jan;13(1):103-110. doi: 10.1080/17460441.2018.1394838. Epub 2017 Oct 31.

37:Cognitive and behavioral disorders in Parkinson's disease: an update. I: cognitive impairments.
Authors:Papagno C, Trojano L
Institution:CIMeC, University of Trento, Trento, Italy. costanza.papagno@unimib.it. 02100, Milan, Italy. costanza.papagno@unimib.it. Ellittico 31, 81100, Caserta, Italy. luigi.trojano@unicampania.it.
Journal:Neurol Sci. 2018 Feb;39(2):215-223. doi: 10.1007/s10072-017-3154-8. Epub 2017 Oct 17.

38:Nutritional habits, risk, and progression of Parkinson disease.
Authors:Erro R, Brigo F, Tamburin S, Zamboni M, Antonini A, Tinazzi M
Institution:Department of Neuroscience, Biomedicine and Movement Science, University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. erro.roberto@gmail.com. University of Salerno, Salerno, Italy. erro.roberto@gmail.com. Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. of Verona, Verona, Italy. Universitaria Padua, Padua, Italy. Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
Journal:J Neurol. 2018 Jan;265(1):12-23. doi: 10.1007/s00415-017-8639-0. Epub 2017 Oct 10.

39:Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson's disease: a systematic review with meta-analysis.
Authors:Dos Santos Delabary M, Komeroski IG, Monteiro EP, Costa RR, Haas AN
Institution:Physical Education School, Federal University of Rio Grande do Sul, Street Felizardo, 750-Jardim Botanico, Porto Alegre, Rio Grande Do Sul, CEP 90690-200, Brazil. marcela_delabary@yahoo.com.br.; Federal Foundation School of Medical Sciences of Porto Alegre, Street Sarmento Leite, 245 Centro Historico, Porto Alegre, Rio Grande Do Sul, CEP 90050-170, Brazil.
Journal:Aging Clin Exp Res. 2018 Jul;30(7):727-735. doi: 10.1007/s40520-017-0836-2. Epub 2017 Oct 4.

40:Botulinum toxin in parkinsonism: The when, how, and which for botulinum toxin injections.
Authors:Cardoso F
Institution:Movement Disorders Unit, Neurology Service, Internal Medicine Department, The Federal University of Minas Gerais, Brazil. Electronic address: cardosofe@terra.com.br.
Journal:Toxicon. 2018 Jun 1;147:107-110. doi: 10.1016/j.toxicon.2017.08.018. Epub 2017 Aug 23.

41:Levodopa in Parkinson's Disease: Current Status and Future Developments.
Authors:Tambasco N, Romoli M, Calabresi P
Institution:Clinica Neurologica, Azienda Ospedaliera-Universita di Perugia, Perugia, Italy.
Journal:Curr Neuropharmacol. 2018;16(8):1239-1252. doi: 10.2174/1570159X15666170510143821.

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