| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Li C, An H, Wang J, Jiang Z, Zhang T, Huo Q |
| Institution: | First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan. Xintai People's Hospital, Xintai. | | Journal: | Medicine (Baltimore). 2020 Sep 18;99(38):e22265. doi: 10.1097/MD.0000000000022265. |
| Authors: | Watanabe H, Hattori T, Kume A, Misu K, Ito T, Koike Y, Johnson TA, Kamitsuji S, Kamatani N, Sobue G |
| Institution: | Nagoya University Graduate School of Medicine, Brain and Mind Research Center, Nagoya. | | Journal: | Medicine (Baltimore). 2020 Aug 28;99(35):e21576. doi: 10.1097/MD.0000000000021576. |
| Authors: | Prasad S, Holla VV, Neeraja K, Surisetti BK, Kamble N, Yadav R, Pal PK |
| Institution: | Department of Clinical Neurosciences; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India. | | Journal: | Neurol India. 2020 Jul-Aug;68(4):792-795. doi: 10.4103/0028-3886.293472. |
| Authors: | Hong JY, Sunwoo MK, Yoon JH, Kang SY, Sohn YH, Lee PH, Kim SH |
| Institution: | Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, South Korea. | | Journal: | PLoS One. 2020 Aug 20;15(8):e0237472. doi: 10.1371/journal.pone.0237472. eCollection 2020. |
| Authors: | Lo Buono V, Palmeri R, Stroscio G, Corallo F, Di Lorenzo G, Sorbera C, Ciurleo R, Cimino V, Bramanti P, Marino S, Bonanno L |
| Institution: | IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy. | | Journal: | Medicine (Baltimore). 2020 Aug 7;99(32):e21578. doi: 10.1097/MD.0000000000021578. |
| Authors: | Carapellotti AM, Stevenson R, Doumas M |
| Institution: | School of Psychology, Queen's University Belfast, Belfast, United Kingdom. | | Journal: | PLoS One. 2020 Aug 5;15(8):e0236820. doi: 10.1371/journal.pone.0236820. eCollection 2020. |
| Authors: | Quinn L, Macpherson C, Long K, Shah H |
| Institution: | Department of Biobehavioral Sciences, Teachers College, Columbia University, and Department of Rehabilitation and Regenerative Medicine (Physical Therapy), Columbia University Irving Medical Center, 52 Department of Neurology, Columbia University Irving Medical Center. | | Journal: | Phys Ther. 2020 Sep 28;100(10):1730-1736. doi: 10.1093/ptj/pzaa128. |
| Authors: | Chang YP, Lee MS, Wu DW, Tsai JH, Ho PS, Lin CR, Chuang HY |
| Institution: | Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Program in Environmental and Occupation Medicine, (Taiwan) National Health Research Institutes and Kaohsiung Medical University, Kaohsiung, Taiwan. | | Journal: | PLoS One. 2020 Jul 27;15(7):e0236443. doi: 10.1371/journal.pone.0236443. eCollection 2020. |
| Authors: | Jin Z, Liu Z, Kang L, Yang A, Zhao H, Yan X, Zhang T, Gao L, Liu A, Fang B |
| Institution: | Parkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University. | | Journal: | Medicine (Baltimore). 2020 Jul 10;99(28):e21145. doi: 10.1097/MD.0000000000021145. |
| Authors: | Bove F, Fraix V, Cavallieri F, Schmitt E, Lhommée E, Bichon A, Meoni S, Pélissier P, Kistner A, Chevrier E, Ardouin C, Limousin P, Krack P, Benabid AL, Chabardès S, Seigneuret E, Castrioto A, Moro E |
| Institution: | From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Insti | | Journal: | Neurology. 2020 Jul 28;95(4):e384-e392. doi: 10.1212/WNL.0000000000009822. Epub 2020 Jul 1. |
| Authors: | Hacker ML, Turchan M, Heusinkveld LE, Currie AD, Millan SH, Molinari AL, Konrad PE, Davis TL, Phibbs FT, Hedera P, Cannard KR, Wang L, Charles D |
| Institution: | From the Departments of Neurology (M.L.H., M.T., L.E.H., A.D.C., S.H.M., A.L.M., T.L.D., F.T.P., P.H., D.C.), Neurosurgery (P.E.K.), and Biostatistics (L.W.), Vanderbilt University Medical Center, Nash | | Journal: | Neurology. 2020 Jul 28;95(4):e393-e401. doi: 10.1212/WNL.0000000000009946. Epub 2020 Jun 29. |
| Authors: | Volc D, Poewe W, Kutzelnigg A, Lührs P, Thun-Hohenstein C, Schneeberger A, Galabova G, Majbour N, Vaikath N, El-Agnaf O, Winter D, Mihailovska E, Mairhofer A, Schwenke C, Staffler G, Medori R |
| Institution: | Confraternitaet-Privatklinik Josefstadt, Vienna, Austria. AFFiRiS, Vienna, Austria. | | Journal: | Lancet Neurol. 2020 Jul;19(7):591-600. doi: 10.1016/S1474-4422(20)30136-8. |
| Authors: | López-Liria R, Parra-Egeda J, Vega-Ramírez FA, Aguilar-Parra JM, Trigueros-Ramos R, Morales-Gázquez MJ, Rocamora-Pérez P |
| Institution: | Health Research Centre, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera del Sacramento s/n, La Canada de San Urbano, 04120 Almeria, Spain. | | Journal: | Int J Environ Res Public Health. 2020 Jun 9;17(11):4104. doi: 10.3390/ijerph17114104. |
| Authors: | Fasano A, Cereda E, Barichella M, Cassani E, Ferri V, Zecchinelli AL, Pezzoli G |
| Institution: | Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario Fondazione Grigioni per il Morbo di Parkinson, Italy. | | Journal: | Mov Disord. 2020 Jul;35(7):1089-1093. doi: 10.1002/mds.28176. Epub 2020 Jun 26. |
| Authors: | Cilia R, Bonvegna S, Straccia G, Andreasi NG, Elia AE, Romito LM, Devigili G, Cereda E, Eleopra R |
| Institution: | Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Parkinson and Movement Disorders Unit, Milan, Italy. | | Journal: | Mov Disord. 2020 Aug;35(8):1287-1292. doi: 10.1002/mds.28170. Epub 2020 Jun 11. |
| Authors: | Zhang Q, Yang X, Song H, Jin Y |
| Institution: | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address: zhangqi139139@163.com. Department of Nursing, Tianjin Huanhu Hospital, Tianjin, China. Electronic address: jinyi6196@163.com. | | Journal: | Complement Ther Clin Pract. 2020 May;39:101111. doi: 10.1016/j.ctcp.2020.101111. Epub 2020 Jan 30. |
| Authors: | Mappin-Kasirer B, Pan H, Lewington S, Kizza J, Gray R, Clarke R, Peto R |
| Institution: | From the Clinical Trial Service Unit and Epidemiological Studies Unit (B.M.-K., H.P., S.L., J.K., R.G., R.C., R.P.), Nuffield Department of Population Health, University of Oxford; and Medical Research | | Journal: | Neurology. 2020 May 19;94(20):e2132-e2138. doi: 10.1212/WNL.0000000000009437. Epub 2020 May 5. |
| Authors: | Bougea A, Koros C, Simitsi AM, Chrysovitsanou C, Leonardos A, Stefanis L |
| Institution: | 1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: annita139@yahoo.gr. | | Journal: | Complement Ther Clin Pract. 2020 May;39:101154. doi: 10.1016/j.ctcp.2020.101154. Epub 2020 Mar 31. |
| Authors: | Smirnov DS, Galasko D, Edland SD, Filoteo JV, Hansen LA, Salmon DP |
| Institution: | From the Department of Neurosciences (D.S.S., D.G., D.P.S.), Department of Family Medicine and Public Health (S.D.E.), Departments of Psychiatry and Neurosciences (J.V.F.), and Departments of Pathology | | Journal: | Neurology. 2020 May 19;94(20):e2076-e2087. doi: 10.1212/WNL.0000000000009434. Epub 2020 Apr 24. |
| Authors: | Beck EN, Wang MTY, Intzandt BN, Almeida QJ, Ehgoetz Martens KA |
| Institution: | School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland. Department of Kinesiology and Physical Education, Movement Disorders Research & Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada. | | Journal: | PLoS One. 2020 Apr 16;15(4):e0230803. doi: 10.1371/journal.pone.0230803. eCollection 2020. |
| Authors: | Mitchell KT, Ostrem JL |
| Institution: | Duke University Movement Disorders Center, DUMC 3333, 932 Morreene Road, Durham, NC 27705, USA. Electronic address: kyle.mitchell@duke.edu. UCSF Movement Disorders and Neuromodulation Center, 1635 Divisadero Street Suite 520, Box 1838, San Francisco, CA 94115, USA. | | Journal: | Neurol Clin. 2020 May;38(2):293-307. doi: 10.1016/j.ncl.2020.01.001. Epub 2020 Feb 22. |
| Authors: | Goldman JG, Guerra CM |
| Institution: | Parkinson's Disease and Movement Disorders, Shirley Ryan AbilityLab, 355 East Erie Street, Chicago, IL 60611, USA; Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern Univer PRISMA Advanced Care Center for Parkinson's, movement disorders and Dementia, San Luis Potosi, Mexico; Facutly of Psychology, Autonomous University of San Luis Potosi Sierra de las Cascadas 117, Lomas | | Journal: | Neurol Clin. 2020 May;38(2):269-292. doi: 10.1016/j.ncl.2019.12.003. Epub 2020 Feb 12. |
| Authors: | Poewe W, Mahlknecht P |
| Institution: | Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria. Electronic address: WERNER.POEWE@I-MED.AC.AT. | | Journal: | Neurol Clin. 2020 May;38(2):255-267. doi: 10.1016/j.ncl.2019.12.002. Epub 2020 Feb 20. |
| Authors: | Chakraborty A, Brauer S, Diwan A |
| Institution: | Allexcel, Inc., 1 Controls Drive, Shelton, CT 06484, United States. Electronic address: ashokkchakraborty@gmail.com. | | Journal: | J Clin Neurosci. 2020 Jun;76:1-4. doi: 10.1016/j.jocn.2020.03.047. Epub 2020 Apr 9. |
| Authors: | Chakraborty A, Brauer S, Diwan A |
| Institution: | Allexcel, Inc., 1 Controls Drive, Shelton 06484, CT, United States. Electronic address: ashok.chakraborty@allexcel.com. | | Journal: | J Clin Neurosci. 2020 May;75:1-4. doi: 10.1016/j.jocn.2020.03.024. Epub 2020 Apr 1. |
| Authors: | de Bie RMA, Clarke CE, Espay AJ, Fox SH, Lang AE |
| Institution: | Amsterdam University Medical Centers, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON, Cana | | Journal: | Lancet Neurol. 2020 May;19(5):452-461. doi: 10.1016/S1474-4422(20)30036-3. Epub 2020 Mar 12. |
| Authors: | Kojoh A, Enatsu R, Kitagawa M, Mikami T, Sasagawa A, Kuribara T, Hirano T, Arihara M, Mikuni N |
| Institution: | Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan. | | Journal: | J Clin Neurosci. 2020 Apr;74:244-247. doi: 10.1016/j.jocn.2020.02.014. Epub 2020 Feb 15. |
| Authors: | Mozaffari S, Nikfar S, Daniali M, Abdollahi M |
| Institution: | Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), the Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences , Tehran, Iran. | | Journal: | Expert Opin Pharmacother. 2020 Apr;21(6):701-707. doi: 10.1080/14656566.2020.1726319. Epub 2020 Feb 8. |
| Authors: | Lo Monaco MR, Petracca M, Vetrano DL, Di Stasio E, Fusco D, Ricciardi D, Laudisio A, Zuccalà G, Onder G, Bentivoglio AR |
| Institution: | Institute of Internal Medicine and Geriatrics, Universita Cattolica del Sacro Cuore, 00168, Rome, Italy. rita.lomonaco@gmail.com. Fondazione Policlinico Universitario 'Agostino Gemelli'-IRCSS, Largo A Gemelli, 8, 00168, Rome, Italy. | | Journal: | Aging Clin Exp Res. 2020 Jul;32(7):1369-1373. doi: 10.1007/s40520-020-01469-4. Epub 2020 Jan 24. |
| Authors: | Jiang DQ, Li MX, Jiang LL, Chen XB, Zhou XW |
| Institution: | Department of Biology and Pharmacy, Yulin Normal University, Jiaoyudong Road No.1303, Yuzhou District, Yulin, 537000, Guangxi, China. zhouxw556@163.com. | | Journal: | Aging Clin Exp Res. 2020 May;32(5):769-779. doi: 10.1007/s40520-019-01232-4. Epub 2019 Jun 7. |
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What Our Customers Are Saying... "I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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Russelsheim, Germany
"I found your Guidebook on Parkinson's to be very informative for me, the patient, and for my husband. I am in the process of changing my medication and the book explained more to me than the doctor attempted to. I am now more aware of what to expect. It also offered valuable advice for the caregiver. Thank you."
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Palm Spring, California
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Research Triangle Park, NC
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