Sjogren's Syndrome
March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Immediate Amelioration of Severe Respiratory Distress in Sjögren's Syndrome with COVID-19 Treated with a Single Dose of Off-label Tocilizumab.
Authors:Kataoka H, Kodama F, Tomita T, Kondo M, Nagasaka A, Nishikawa S, Mukai M
Institution:Department of Rheumatology and Clinical Immunology, Sapporo City General Hospital, Japan.
Journal:Intern Med. 2021 Feb 15;60(4):639-643. doi: 10.2169/internalmedicine.6010-20. Epub 2020 Dec 29.

2:Innate Immunity and Biological Therapies for the Treatment of Sjögren's Syndrome.
Authors:Srivastava A, Makarenkova HP
Institution:Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.
Journal:Int J Mol Sci. 2020 Dec 1;21(23):9172. doi: 10.3390/ijms21239172.

3:Minor salivary gland biopsy: Its role in the classification and prognosis of Sjögren's syndrome.
Authors:Bautista-Vargas M, Vivas AJ, Tobón GJ
Institution:GIRAT: Grupo de Investigacion en Reumatologia, Autoinmunidad y Medicina Traslacional, Fundacion Valle Del Lili and Universidad Icesi, Cali, Colombia. Electronic address:
Journal:Autoimmun Rev. 2020 Dec;19(12):102690. doi: 10.1016/j.autrev.2020.102690. Epub 2020 Oct 22.

4:Mediterranean diet and risk of Sjögren's syndrome.
Authors:Machowicz A, Hall I, de Pablo P, Rauz S, Richards A, Higham J, Poveda-Gallego A, Imamura F, Bowman SJ, Barone F, Fisher BA
Institution:Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, UK. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, UK.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):216-221. Epub 2020 Oct 23.

5:Primary Sjögren's syndrome: central and peripheral nervous system involvements.
Authors:Mekinian A, Tennenbaum J, Lahuna C, Dellal A, Belfeki N, Capron J, Januel E, Stankoff B, Alamowitch S, Fain O
Institution:Sorbonne Universite, AP-HP, Hopital Saint-Antoine, Service de Medecine Interne and Inflammation-Immunopathology-Biotherapy Department (DMU i3), Paris, France.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):103-109. Epub 2020 Oct 22.

6:Interstitial lung disease in Sjögren's syndrome: a clinical review.
Authors:Luppi F, Sebastiani M, Silva M, Sverzellati N, Cavazza A, Salvarani C, Manfredi A
Institution:Department of Medicine and Surgery, University of Milan Bicocca, Respiratory Unit, San Gerardo Hospital, ASST Monza, Italy. Chair and Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):291-300. Epub 2020 Oct 23.

7:Clinically significant renal involvement in primary Sjögren's syndrome is associated with important morbidity: data from the Spanish Sjögrenser cohort.
Authors:Narvaez J, Sánchez-Piedra C, Fernández-Castro M, Martínez-Taboada V, Olivé A, Rosas J, García-Vadillo JA, Júdez E, Ruiz-Lucea E, Romani L, Montalá N, Andreu JL
Institution:Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain. Department of Rheumatology, Hospital Puerto de Hierro, Madrid, Spain.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):116-124. Epub 2020 Oct 22.

8:Digestive involvement in primary Sjögren's syndrome: analysis from the Sjögrenser registry.
Authors:Melchor S, Sánchez-Piedra C, Fernández Castro M, Andreu JL, Martínez Taboada V, Olivé A, Rosas J, Menor R, García-Aparicio Á, López Longo FJ, Manrique-Arija S, García Vadillo JA, López González R, Narváez J, Galisteo C, González Martín J, Naranjo A, Illera Ó, Moreira B, Raya E, Rodríguez López M, Júdez E, Moriano C, Torrente-Segarra V, García Magallón B, Guillén Astete C, Castellvi I, Bohórquez C, Loricera J, Belzunegui J, Carreira PE
Institution:Rheumatology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):110-115. Epub 2020 Oct 1.

9:10-year follow-up of patients with rheumatoid arthritis and secondary Sjögren's syndrome or sicca symptoms in daily clinical practice.
Authors:Moerman RV, Arends S, Mossel E, Kroese FGM, Vissink A, Bootsma H
Institution:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, the Netherlands.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):64-72. Epub 2020 Sep 23.

10:One year in review 2020: pathogenesis of primary Sjögren's syndrome.
Authors:Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, Lucchesi D, Fulvio G, Tzioufas AG, Baldini C
Institution:Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK. Rheumatology Unit, Department of Clinical and Experimental Rheumatology, University of Pisa, Italy.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):3-9. Epub 2020 Sep 29.

11:Comorbidity and health care utilisation in persons with Sjögren's syndrome: a claims data analysis.
Authors:Albrecht K, Dörner T, Redeker I, Karberg K, Marschall U, Zink A, Callhoff J
Institution:German Rheumatism Research Centre, Epidemiology Unit, Berlin, Germany.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):78-84. Epub 2020 Sep 18.

12:Extraglandular ocular involvement and morbidity and mortality in primary Sjögren's Syndrome.
Authors:Mathews PM, Robinson SA, Gire A, Baer AN, Akpek EK
Institution:Ocular Surface Disease Clinic, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Journal:PLoS One. 2020 Sep 25;15(9):e0239769. doi: 10.1371/journal.pone.0239769. eCollection 2020.

13:Increased risk of developing dental diseases in patients with primary Sjögren's syndrome-A secondary cohort analysis of population-based claims data.
Authors:Chuang CJ, Hsu CW, Lu MC, Koo M
Institution:Division of Obstetrics and Gynecology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan. Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Journal:PLoS One. 2020 Sep 18;15(9):e0239442. doi: 10.1371/journal.pone.0239442. eCollection 2020.

14:One year in review 2020: comorbidities, diagnosis and treatment of primary Sjögren's syndrome.
Authors:Manfrè V, Cafaro G, Riccucci I, Zabotti A, Perricone C, Bootsma H, De Vita S, Bartoloni E
Institution:Clinic of Rheumatology, DAME, University Hospital S. Maria della Misericordia, Udine, Italy. Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):10-22. Epub 2020 Sep 16.

15:Serious infections in Sjögren's syndrome patients: a national U.S. study.
Authors:Singh JA, Cleveland JD
Institution:Medicine Service, VA Medical Center, Birmingham; Department of Medicine at School of Medicine; and Division of Epidemiology at School of Public Health, University of Alabama at Birmingham, AL, USA. Department of Medicine at School of Medicine, University of Alabama at Birmingham, AL, USA.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):47-52. Epub 2020 Sep 2.

16:Does Nasal Secretion Decrease in Sjögren Syndrome and Does This Affect Nasal Function?
Authors:Eren E, Balcı K, Gerçik Ö, Kabadayı G, Akar S
Institution:Department of Otolaryngology-Head & Neck Surgery, Izmir Ataturk Research and Education Hospital, ?zmir, Turkey. Department of Rheumatology, Izmir Katip Celebi University Ataturk Research and Education Hospital, ?zmir, Turkey.
Journal:Laryngoscope. 2021 Feb;131(2):370-373. doi: 10.1002/lary.29022. Epub 2020 Aug 11.

17:Focus on Effects of Chinese Medicine on Improving Anxiety-Depression and Quality of Life of Patients with Primary Sjögren's Syndrome.
Authors:Wu GL, Li TY
Institution:Department of Traditional Chinese Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. Basic Medical College, Zhejiang University of Chinese Medicine, Hangzhou, 310053, China.
Journal:Chin J Integr Med. 2020 Jul;26(7):486-489. doi: 10.1007/s11655-020-3473-0. Epub 2020 Jul 6.

18:Ocular Manifestations and Burden Related to Sjögren Syndrome: Results of a Patient Survey.
Authors:Saldanha IJ, Bunya VY, McCoy SS, Makara M, Baer AN, Akpek EK
Institution:Center for Evidence Synthesis in Health, Department of Health Services, Policy, and Practice, and Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA. Electronic address: The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal:Am J Ophthalmol. 2020 Nov;219:40-48. doi: 10.1016/j.ajo.2020.05.043. Epub 2020 Jun 20.

19:Quantitative analysis of Sjogren's syndrome related interstitial lung disease with different methods.
Authors:Ufuk F, Demirci M, Altinisik G, Karasu U
Institution:Department of Radiology, University of Pamukkale, Kinikli, 20100 Denizli, Turkey. Electronic address: Department of Rheumatology, University of Pamukkale, Kinikli, 20100 Denizli, Turkey.
Journal:Eur J Radiol. 2020 Jul;128:109030. doi: 10.1016/j.ejrad.2020.109030. Epub 2020 May 7.

20:Fibromyalgia, Sjogren's & depression: linked?
Authors:Loganathan M, Ladani A, Lippmann S
Institution:Department of Behavior Medicine and Psychiatry, West Virginia University , Morgantown, WV, USA. Department of Psychiatry, University of Louisville School of Medicine , Louisville, KY, USA.
Journal:Postgrad Med. 2020 Sep;132(7):575-580. doi: 10.1080/00325481.2020.1758426. Epub 2020 May 20.

21:Prevalence of Sjögren's syndrome associated with rheumatoid arthritis in the USA: an observational study from the Corrona registry.
Authors:Harrold LR, Shan Y, Rebello S, Kramer N, Connolly SE, Alemao E, Kelly S, Kremer JM, Rosenstein ED
Institution:Corrona, LLC, 1440 Main Street, Suite 310, Waltham, MA, 02451, USA. Institute for Rheumatic & Autoimmune Diseases, Overlook Medical Center, Summit, NJ, USA.
Journal:Clin Rheumatol. 2020 Jun;39(6):1899-1905. doi: 10.1007/s10067-020-05004-8. Epub 2020 Mar 4.

22:Vaginal dryness in primary Sjögren's syndrome: a histopathological case-control study.
Authors:van Nimwegen JF, van der Tuuk K, Liefers SC, Verstappen GM, Visser A, Wijnsma RF, Vissink A, Hollema H, Mourits MJE, Bootsma H, Kroese FGM
Institution:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Journal:Rheumatology (Oxford). 2020 Oct 1;59(10):2806-2815. doi: 10.1093/rheumatology/keaa017.

23:Risk of non-Hodgkin's lymphoma and thyroid cancer in primary Sjögren's syndrome measured using the Korean Health Insurance Claims Database.
Authors:Ahn JK, Hwang J, Seo GH
Institution:Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Health Insurance Review and Assessment Service, Wonju, Republic of Korea.
Journal:Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):40-46. Epub 2020 Jan 22.

24:Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome.
Authors:Brito-Zerón P, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Armagan B, Kruize AA, Kwok SK, Kvarnstrom M, Praprotnik S, Sene D, Gerli R, Solans R, Rischmueller M, Mandl T, Suzuki Y, Isenberg D, Valim V, Wiland P, Nordmark G, Fraile G, Bootsma H, Nakamura H, Giacomelli R, Devauchelle-Pensec V, Hofauer B, Bombardieri M, Trevisani VFM, Hammenfors D, Pasoto SG, Retamozo S, Gheita TA, Atzeni F, Morel J, Vollenweider C, Zeher M, Sivils K, Xu B, Bombardieri S, Sandhya P, De Vita S, Minniti A, Sánchez-Guerrero J, Kilic L, van der Heijden E, Park SH, Wahren-Herlenius M, Mariette X, Ramos-Casals M
Institution:Department of Medicine, Autoimmune Diseases Unit, Hospital CIMA - Sanitas, Barcelona, Spain. Sjogren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clinic, Barcelona, Spain.
Journal:Rheumatology (Oxford). 2020 Sep 1;59(9):2350-2359. doi: 10.1093/rheumatology/kez578.

25:Psychological status and disease activity were major predictors of body image disturbances in patients with Sjögren's syndrome.
Authors:Li Z, Wang Y, Dong C, Guo J, Fu T, Li L, Gu Z
Institution:Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Journal:Psychol Health Med. 2020 Jun;25(5):572-582. doi: 10.1080/13548506.2019.1648838. Epub 2019 Aug 2.

26:American Indians Have a Higher Risk of Sjögren's Syndrome and More Disease Activity Than European Americans and African Americans.
Authors:Scofield RH, Sharma R, Pezant N, Kelly JA, Radfar L, Lewis DM, Kaufman CE, Cioli S, Harris J, Grundahl K, Rhodus NL, Wallace DJ, Weisman MH, Venuturupalli S, Brennan MT, Koelsch KA, Lessard CJ, Montgomery CG, Sivils KL, Rasmussen A
Institution:Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and Department of Veterans Affairs Medical Center, Oklahoma City. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, and Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
Journal:Arthritis Care Res (Hoboken). 2020 Aug;72(8):1049-1056. doi: 10.1002/acr.24003. Epub 2020 Jul 5.

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