Sjogren's Syndrome
September 2021 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Characteristics and mortality in primary Sjögren syndrome-related interstitial lung disease.
Authors:Gao H, Sun Y, Zhang XY, Xie L, Zhang XW, Zhong YC, Zhang J, Hou YK, Li ZG
Institution:Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China. Beijing, China. Beijing, China. Beijing, China. Beijing, China. Beijing, China. Beijing, China. Beijing, China. Beijing, China.
Journal:Medicine (Baltimore). 2021 Sep 3;100(35):e26777. doi: 10.1097/MD.0000000000026777.

2:Metformin as a Treatment Strategy for Sjögren's Syndrome.
Authors:Kim J, Kim YS, Park SH
Institution:Division of Rheumatology, Department of Internal Medicine, Chosun University Hospital, Gwangju 61453, Korea. Hospital, Gwangju 61453, Korea. Catholic University of Korea, Seoul 06591, Korea.
Journal:Int J Mol Sci. 2021 Jul 5;22(13):7231. doi: 10.3390/ijms22137231.

3:Efficacy and safety of Tripterygium glycosides in Sjögren's syndrome treatment: evidence from 12 randomized controlled trials.
Authors:Luo Y, Zhang Y, Kuai L, Xing M, Ru Y
Institution:Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Shanghai, China. Shanghai, China. Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Journal:Ann Palliat Med. 2021 Jul;10(7):8215-8231. doi: 10.21037/apm-21-256. Epub 2021 Jul 5.

4:Cardiovascular Risk and Endothelial Dysfunction in Primary Sjogren Syndrome Is Related to the Disease Activity.
Authors:Łuczak A, Małecki R, Kulus M, Madej M, Szahidewicz-Krupska E, Doroszko A
Institution:Department of Rheumatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. Borowska 213, 50-556 Wroclaw, Poland. 6a, 50-367 Wroclaw, Poland.
Journal:Nutrients. 2021 Jun 17;13(6):2072. doi: 10.3390/nu13062072.

5:Is Sjogren's syndrome a risk factor/contraindication for dental implants? An umbrella review.
Authors:Barros AWP, Sales PHDH, Carvalho AAT, Patel P, Porter S, Leão JC
Institution:Programa de Pós-Graduação em Odontologia, Departamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil. Preventiva, Universidade Federal de Pernambuco, Recife, Brazil. Preventiva, Universidade Federal de Pernambuco, Recife, Brazil.
Journal:Spec Care Dentist. 2021 Jul;41(4):453-462. doi: 10.1111/scd.12591. Epub 2021 May 13.

6:Peripheral Nervous System Involvement in Sjögren's Syndrome: Analysis of a Cohort From the Italian Research Group on Sjögren's Syndrome.
Authors:Cafaro G, Perricone C, Carubbi F, Baldini C, Quartuccio L, Priori R, Berardicurti O, Ferro F, Gandolfo S, Gattamelata A, Giacomelli R, De Vita S, Gerli R, Bartoloni E
Institution:Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy. Science, University of L'Aquila, L'Aquila, Italy. Pisa, Pisa, Italy. Udine, Udine, Italy. University of Rome, Rome, Italy. Science, University of L'Aquila, L'Aquila, Italy. Pisa, Pisa, Italy. Udine, Udine, Italy. University of Rome, Rome, Italy. Science, University of L'Aquila, L'Aquila, Italy. Udine, Udine, Italy.
Journal:Front Immunol. 2021 Mar 24;12:615656. doi: 10.3389/fimmu.2021.615656. eCollection 2021.

7:Stimulated whole salivary flow rate: The most appropriate technique for assessing salivary flow in Sjögren syndrome.
Authors:Alvariño C, Bagan L, Murillo-Cortes J, Calvo J, Bagan J
Institution:Prof. Jose Vte. Bagan Service of Stomatology and Maxillofacial Surgery University General Hospital Avda Tres Cruces 2, 46014, Valencia, Spain bagan@uv.es.
Journal:Med Oral Patol Oral Cir Bucal. 2021 May 1;26(3):e404-e407. doi: 10.4317/medoral.24736.

8:Neurological Involvement in Patients With Primary Sjögren's Syndrome.
Authors:Fan G, Dai F, Chen S, Sun Y, Qian H, Yang G, Liu Y, Shi G
Institution:From the School of Medicine, Xiamen University.
Journal:J Clin Rheumatol. 2021 Mar 1;27(2):50-55. doi: 10.1097/RHU.0000000000001128.

9:Pulmonary amyloidosis and cystic lung disease in primary Sjögren's syndrome: a case report and literature review.
Authors:Li H, Lu Y
Institution:Department of Rheumatology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.
Journal:Clin Rheumatol. 2021 Aug;40(8):3345-3350. doi: 10.1007/s10067-021-05596-9. Epub 2021 Jan 25.

10:Topical cyclosporine a (0.05%) treatment in dry eye patients: a comparison study of Sjogren's syndrome versus non-Sjogren's syndrome.
Authors:Cubuk MO, Ucgul AY, Ozgur A, Ozulken K, Yuksel E
Institution:Department of Ophthalmology, Istanbul Research and Education Hospital, Istanbul, Turkey. Faculty of Medicine, Department of Ophthalmology, Kastamonu University, Kastamonu, Turkey. rdmyksl@yahoo.com.
Journal:Int Ophthalmol. 2021 Apr;41(4):1479-1485. doi: 10.1007/s10792-021-01708-1. Epub 2021 Jan 23.

11:Ocular Involvement in Sjögren Syndrome: Risk Factors for Severe Visual Impairment and Vision-Threatening Corneal Complications.
Authors:Singh S, Das AV, Basu S
Institution:Center for Ocular Regeneration, LV Prasad Eye Institute, Hyderabad, Telangana, India; Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad, Telangana, India. Hyderabad, Telangana, India. India; Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad, Telangana, India; The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address: sayanbasu@lvpei.org.
Journal:Am J Ophthalmol. 2021 May;225:11-17. doi: 10.1016/j.ajo.2020.12.019. Epub 2020 Dec 29.

12:What's new in ocular and oral aspects of Sjögren's syndrome and do new treatments work?
Authors:Sutcliffe N, Recchioni A, Hilmi S, Rauz S, Tappuni AR
Institution:Department of Rheumatology, Barts Health NHS Trust, London, UK. Institute of Dentistry, Queen Mary University of London, London, UK.
Journal:Rheumatology (Oxford). 2021 Mar 2;60(3):1034-1041. doi: 10.1093/rheumatology/keaa854.

13:SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients.
Authors:Brito-Zerón P, Melchor S, Seror R, Priori R, Solans R, Kostov B, Baldini C, Carubbi F, Callejas JL, Guisado-Vasco P, Hernández-Molina G, Pasoto SG, Valim V, Sisó-Almirall A, Mariette X, Carreira P, Ramos-Casals M
Institution:Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain.
Journal:Rheumatology (Oxford). 2021 Jun 18;60(6):2946-2957. doi: 10.1093/rheumatology/keaa748.

14:Childhood Sjögren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria.
Authors:Basiaga ML, Stern SM, Mehta JJ, Edens C, Randell RL, Pomorska A, Irga-Jaworska N, Ibarra MF, Bracaglia C, Nicolai R, Susic G, Boneparth A, Srinivasalu H, Dizon B, Kamdar AA, Goldberg B, Knupp-Oliveira S, Antón J, Mosquera JM, Appenzeller S, O'Neil KM, Protopapas SA, Saad-Magalhães C, Akikusa JD, Thatayatikom A, Cha S, Nieto-González JC, Lo MS, Treemarcki EB, Yokogawa N, Lieberman SM
Institution:Division of Pediatric Rheumatology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. Medicine, Salt Lake City, UT, USA. USA. Center, Chicago, IL, USA. Gdansk, Poland. Gdansk, Poland. School of Medicine and Health Sciences, Washington, DC, USA. School of Medicine and Health Sciences, Washington, DC, USA. and Skin Diseases, Bethesda, MD, USA. Houston, TX, USA. University School of Medicine, Atlanta, GA, USA. de Janeiro, Brazil. Campinas, São Paulo, Brazil. Medicine and Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA. Medicine and Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA. Paulo, Brazil. Research Institute, Melbourne, Australia. College of Medicine, University of Florida, Gainesville, FL, USA. College of Dentistry, University of Florida, Gainesville, FL, USA. Spain. Harvard Medical School, Boston, MA, USA. Medicine, Salt Lake City, UT, USA. Japan. Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Journal:Rheumatology (Oxford). 2021 Jul 1;60(7):3144-3155. doi: 10.1093/rheumatology/keaa757.

15:Burden of illness among subgroups of patients with primary Sjögren's syndrome and systemic involvement.
Authors:Gairy K, Knight C, Anthony P, Hoskin B
Institution:Value Evidence & Outcomes, GlaxoSmithKline, Brentford, Middlesex, UK.
Journal:Rheumatology (Oxford). 2021 Apr 6;60(4):1871-1881. doi: 10.1093/rheumatology/keaa508.

16:Sialendoscopy and Sjogren's Disease: A Systematic Review.
Authors:Coca KK, Gillespie MB, Beckmann NA, Zhu R, Nelson TM, Witt RL
Institution:Department of Otolaryngology-Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A. Science Center, Memphis, Tennessee, U.S.A. Science Center, Memphis, Tennessee, U.S.A. Tennessee Health Science Center, Memphis, Tennessee, U.S.A. Science Center, Memphis, Tennessee, U.S.A. Philadelphia, Pennsylvania, U.S.A.
Journal:Laryngoscope. 2021 Jul;131(7):1474-1481. doi: 10.1002/lary.29233. Epub 2020 Nov 3.

17:Efficacy and safety of iguratimod on patients with primary Sjögren's syndrome: a randomized, placebo-controlled clinical trial.
Authors:Shao Q, Wang S, Jiang H, Liu L
Institution:Department of Rheumatology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China. Chongqing, China. Chongqing, China. Chongqing, China.
Journal:Scand J Rheumatol. 2021 Mar;50(2):143-152. doi: 10.1080/03009742.2020.1809701. Epub 2020 Oct 29.

18:Biologic therapy in Sjögren's syndrome.
Authors:Shao Q
Institution:Department of Rheumatology, Chongqing City Hospital of Traditional Chinese Medicine, No.6, Pan Xi Qi Zhi Road, Jiang Bei District, Chongqing, 400021, China. qinshao2011@126.com.
Journal:Clin Rheumatol. 2021 Jun;40(6):2143-2154. doi: 10.1007/s10067-020-05429-1. Epub 2020 Oct 27.

19:Sialendoscopy increases saliva secretion and reduces xerostomia up to 60 weeks in Sjögren's syndrome patients: a randomized controlled study.
Authors:Karagozoglu KH, Vissink A, Forouzanfar T, de Visscher JGAM, Maarse F, Brand HS, van de Ven PM, Jager DHJ
Institution:Department of Maxillofacial Surgery and Oral Pathology, Amsterdam University Medical Centers (Amsterdam UMC, Location VUmc) and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal:Rheumatology (Oxford). 2021 Mar 2;60(3):1353-1363. doi: 10.1093/rheumatology/keaa284.

20:A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren's syndrome.
Authors:Juarez M, Diaz N, Johnston GI, Nayar S, Payne A, Helmer E, Cain D, Williams P, Devauchelle-Pensec V, Fisher BA, Giacomelli R, Gottenberg JE, Guggino G, Kvarnström M, Mariette X, Ng WF, Rosas J, Sánchez Bursón J, Triolo G, Barone F, Bowman SJ
Institution:Translational Medicine, UCB Pharma, Slough, UK. National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Journal:Rheumatology (Oxford). 2021 Mar 2;60(3):1364-1375. doi: 10.1093/rheumatology/keaa410.

21:Ankylosing spondylitis coexists with rheumatoid arthritis and Sjögren's syndrome: a case report with literature review.
Authors:Zhao GW, Huang LF, Li D, Zeng Y
Institution:Department of Rheumatology and Clinical Immunology, The First People's Hospital of Yueyang, Yueyang Avenue, 28, Yueyang, Hunan Province, China. 124065013@qq.com.
Journal:Clin Rheumatol. 2021 May;40(5):2083-2086. doi: 10.1007/s10067-020-05350-7. Epub 2020 Sep 16.

22:Clinical practice guidance for Sjögren's syndrome in pediatric patients (2018) - summarized and updated.
Authors:Tomiita M, Kobayashi I, Itoh Y, Inoue Y, Iwata N, Umebayashi H, Okamoto N, Nonaka Y, Hara R, Mori M
Institution:Department of Pediatrics, Pediatric Allergy and Rheumatology Center, NHO Shimoshizu National Hospital, Yotsukaido, Japan. Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Journal:Mod Rheumatol. 2021 Mar;31(2):283-293. doi: 10.1080/14397595.2020.1816319. Epub 2020 Sep 15.

23:Evaluation of changes in oral health-related quality of life over time in patients with Sjögren's syndrome.
Authors:Azuma N, Katada Y, Yoshikawa T, Yokoyama Y, Nishioka A, Sekiguchi M, Kitano M, Kitano S, Sano H, Matsui K
Institution:Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Suita, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. University of Pennsylvania, Philadelphia, PA, USA. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Journal:Mod Rheumatol. 2021 May;31(3):669-677. doi: 10.1080/14397595.2020.1795391. Epub 2020 Jul 30.

24:Iguratimod treatment reduces disease activity in early primary Sjögren's syndrome: An open-label pilot study.
Authors:Chen H, Qi X, Li Y, Wu Q, Shi Q, Wang L, Li J, Zhao L, Zhang L, Zhou X, Fei Y, Liu J, Su J, Wu D, Yang Y, Jiang H, Zeng X, Zhang F, Zhao Y
Institution:Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Medical Sciences & Peking Union Medical College, Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Sciences, Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Beijing, China.
Journal:Mod Rheumatol. 2021 Mar;31(2):394-398. doi: 10.1080/14397595.2020.1789335. Epub 2020 Aug 3.

25:Treatment of Sjögren's syndrome: current therapy and future directions.
Authors:Fox RI, Fox CM, Gottenberg JE, Dörner T
Institution:Rheumatology Clinic, Scripps Memorial Hospital and Research Foundation, La Jolla, CA. CA. Diseases, Strasbourg, France. Universitätsmedizin Berlin & DRFZ Berlin, Berlin, Germany.
Journal:Rheumatology (Oxford). 2021 May 14;60(5):2066-2074. doi: 10.1093/rheumatology/kez142.

26:Comorbidities (excluding lymphoma) in Sjögren's syndrome.
Authors:Pego-Reigosa JM, Restrepo Vélez J, Baldini C, Rúa-Figueroa Fernández de Larrinoa Í
Institution:Rheumatology Department, University Hospital Complex of Vigo, Vigo, Spain. Canaria, Spain.
Journal:Rheumatology (Oxford). 2021 May 14;60(5):2075-2084. doi: 10.1093/rheumatology/key329.

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