Parkinson's Disease
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Shoulder Dysfunction in Parkinson Disease: Review of Clinical, Imaging Findings and Contributing Factors.
Authors:Paggou D, Stefanis L, Chronopoulos E, Ghika A, Kyrozis A, Balanika A, Baltas C, Potagas C
Institution:First Department of Neurology, National and Kapodistrian University of Athens, 'Aeginition' University Hospital of Athens, Greece.
Journal:J Musculoskelet Neuronal Interact. 2023 Jun 1;23(2):263-280.

2:Natural Products as the Potential to Improve Alzheimer's and Parkinson's Disease.
Authors:Kim SW, Lee JH, Kim B, Yang G, Kim JU
Institution:College of Korea Medicine, Woosuk University, Jeonju-si 54986, Republic of Korea.
Journal:Int J Mol Sci. 2023 May 16;24(10):8827. doi: 10.3390/ijms24108827.

3:Uncovering Novel Therapeutic Targets for Parkinson's Disease.
Authors:Soni R, Delvadia P, Joharapurkar A, Shah J
Institution:Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India.
Journal:ACS Chem Neurosci. 2023 Jun 7;14(11):1935-1949. doi: 10.1021/acschemneuro.3c00084. Epub 2023 May 25.

4:Diabetes mellitus, prediabetes and the risk of Parkinson's disease: a systematic review and meta-analysis of 15 cohort studies with 29.9 million participants and 86,345 cases.
Authors:Aune D, Schlesinger S, Mahamat-Saleh Y, Zheng B, Udeh-Momoh CT, Middleton LT
Institution:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, W2 1PG, Paddington, London, UK.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.
Journal:Eur J Epidemiol. 2023 Jun;38(6):591-604. doi: 10.1007/s10654-023-00970-0. Epub 2023 Apr 25.

5:Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With Meta-Analyses.
Authors:Li JA, Loevaas MB, Guan C, Goh L, Allen NE, Mak MKY, Lv J, Paul SS
Institution:Discipline of Movement Sciences, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Journal:Neurorehabil Neural Repair. 2023 May;37(5):328-352. doi: 10.1177/15459683231172752. Epub 2023 May 11.

6:Role of dopamine agonists in Parkinson's disease therapy.
Authors:Woitalla D, Buhmann C, Hilker-Roggendorf R, Höglinger G, Koschel J, Müller T, Weise D
Institution:Department of Neurology, Katholische Kliniken Der Ruhrhalbinsel, Essen, Germany.; Department of Neurology, Asklepios Fachklinikum Stadtroda, Stadtroda, Germany.
Journal:J Neural Transm (Vienna). 2023 Jun;130(6):863-873. doi: 10.1007/s00702-023-02647-0. Epub 2023 May 11.

7:Parkinson's disease therapy: what lies ahead?
Authors:Wolff A, Schumacher NU, Pürner D, Machetanz G, Demleitner AF, Feneberg E, Hagemeier M, Lingor P
Institution:Department of Neurology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strae 22, 81675, Munich, Germany.
Journal:J Neural Transm (Vienna). 2023 Jun;130(6):793-820. doi: 10.1007/s00702-023-02641-6. Epub 2023 May 5.

8:Could treatment of autonomic dysfunction in early and prodromal Parkinson's disease slow disease progression?
Authors:Doolittle JD
Institution:Department of Neurology, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States.
Journal:J Neurophysiol. 2023 Jun 1;129(6):1279-1281. doi: 10.1152/jn.00380.2022. Epub 2023 May 4.

9:Parkinson's disease and oral health: A systematic review.
Authors:Verhoeff MC, Eikenboom D, Koutris M, de Vries R, Berendse HW, van Dijk KD, Lobbezoo F
Institution:Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address:; Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal:Arch Oral Biol. 2023 Jul;151:105712. doi: 10.1016/j.archoralbio.2023.105712. Epub 2023 Apr 25.

10:Inhaled levodopa for threatening impending OFF episodes in managing Parkinson's disease.
Authors:Jost WH, Kulisevsky J, LeWitt PA
Institution:Parkinson-Klinik Ortenau, Kreuzbergstr. 12-16, 77709, Wolfach, Germany.; Wayne State University School of Medicine (Sastry Foundation Endowed Chair in Neurology and Henry Ford Hospital), Detroit, MI, 48201, USA.
Journal:J Neural Transm (Vienna). 2023 Jun;130(6):821-826. doi: 10.1007/s00702-023-02636-3. Epub 2023 Apr 23.

11:Sex and Gender Differences in Parkinson's Disease.
Authors:Patel R, Kompoliti K
Institution:Rush University Medical Center, 725 West Harrison Street, Suite 755, Chicago, IL, USA; Jesse Brown VA Medical Center, 8542 Damen Pavillion, 820 South Damen Avenue, Chicago, IL 60642, USA. Electronic address:; Rush University Medical Center, 725 West Harrison Street, Suite 755, Chicago, IL, USA.
Journal:Neurol Clin. 2023 May;41(2):371-379. doi: 10.1016/j.ncl.2022.12.001. Epub 2023 Feb 19.

12:Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations.
Authors:Regensburger M, Ip CW, Kohl Z, Schrader C, Urban PP, Kassubek J, Jost WH
Institution:Department of Molecular Neurology, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.; Parkinson-Klinik Ortenau, Wolfach, Germany.
Journal:J Neural Transm (Vienna). 2023 Jun;130(6):847-861. doi: 10.1007/s00702-023-02623-8. Epub 2023 Mar 24.

13:A meta-analysis of exercise intervention and the effect on Parkinson's Disease symptoms.
Authors:Omar Ahmad S, Longhurst J, Stiles D, Downard L, Martin S
Institution:Department of Occupational Science and Occupational Therapy, Saint Louis University, Doisy College of Health Sciences, Saint Louis, MO 63104, USA. Electronic address:; Department of Occupational Science and Occupational Therapy, Saint Louis University, Doisy College of Health Sciences, Saint Louis, MO 63104, USA. Electronic address:
Journal:Neurosci Lett. 2023 Mar 28;801:137162. doi: 10.1016/j.neulet.2023.137162. Epub 2023 Feb 28.

14:The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential.
Authors:Rakshit D, Nayak S, Kundu S, Angelopoulou E, Pyrgelis ES, Piperi C, Mishra A
Institution:Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Changsari, Kamrup, Assam 781101, India.
Journal:ACS Chem Neurosci. 2023 Mar 15;14(6):1033-1044. doi: 10.1021/acschemneuro.2c00789. Epub 2023 Mar 1.

15:Pros and cons for statins use and risk of Parkinson's disease: An updated perspective.
Authors:Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Alsayegh AA, Almohmadi NH, Saad HM, Batiha GE
Institution:Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, Iraq.; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Journal:Pharmacol Res Perspect. 2023 Apr;11(2):e01063. doi: 10.1002/prp2.1063.

16:Pain and Parkinson's disease: Current mechanism and management updates.
Authors:Viseux FJF, Delval A, Simoneau M, Defebvre L
Institution:Centre d'Evaluation et de Traitement de la Douleur, Hopital Jean Bernard, Valenciennes, France.; U1172 Lille Neurosciences & Cognition, CHU Lille, Movement Disorders Department, Lille University, Lille, France.
Journal:Eur J Pain. 2023 May;27(5):553-567. doi: 10.1002/ejp.2096. Epub 2023 Mar 3.

17:Structural and functional changes in the retina in Parkinson's disease.
Authors:Alves JN, Westner BU, Højlund A, Weil RS, Dalal SS
Institution:Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Journal:J Neurol Neurosurg Psychiatry. 2023 Jun;94(6):448-456. doi: 10.1136/jnnp-2022-329342. Epub 2023 Feb 17.

18:A systematic review and meta-analysis of respiratory dysfunction in Parkinson's disease.
Authors:McMahon L, Blake C, Lennon O
Institution:UCD School of Public Health, Physiotherapy and Population Science, Health Sciences Centre, University College Dublin, Dublin, Ireland.
Journal:Eur J Neurol. 2023 May;30(5):1481-1504. doi: 10.1111/ene.15743. Epub 2023 Mar 7.

19:Rheumatic Manifestations of Parkinson's Disease: An Overview.
Authors:Slouma M, Hajji H, Rahmouni S, Dhahri R, Metoui L, Gharsallah I
Institution:Department of Rheumatology, Military Hospital, Tunis, Tunisia.
Journal:Curr Rheumatol Rev. 2023 Jun 5;19(3):294-302. doi: 10.2174/1573397119666230210162808.

20:Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis.
Authors:Monaghan AS, Gordon E, Graham L, Hughes E, Peterson DS, Morris R
Institution:College of Health Solutions, Arizona State University, 5th St., Phoenix, AZ 85282, USA.; Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.
Journal:Neurosci Biobehav Rev. 2023 Apr;147:105068. doi: 10.1016/j.neubiorev.2023.105068. Epub 2023 Feb 2.

21:Sleep and wakefulness disturbances in Parkinson's disease: A meta-analysis on prevalence and clinical aspects of REM sleep behavior disorder, excessive daytime sleepiness and insomnia.
Authors:Maggi G, Vitale C, Cerciello F, Santangelo G
Institution:Department of Psychology, University of Campania 'Luigi Vanvitelli', Caserta, Italy. Electronic address:
Journal:Sleep Med Rev. 2023 Apr;68:101759. doi: 10.1016/j.smrv.2023.101759. Epub 2023 Jan 16.

22:An Apple a Day to Keep the Parkinson's Disease Doctor Away?
Authors:Bloem BR, Post E, Hall DA
Institution:Department of Neurology, Centre of Expertise for Parkinson & Movement Disorders, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.; Department of Neurological Sciences, Rush University, Chicago, IL, USA.
Journal:Ann Neurol. 2023 Apr;93(4):681-685. doi: 10.1002/ana.26612. Epub 2023 Feb 9.

23:Non-visual hallucinations in Parkinson's disease: a systematic review.
Authors:Toh WL, Yolland C, Gurvich C, Barnes J, Rossell SL
Institution:Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University of Technology, Melbourne, PO Box 218, Hawthorn, 3122, VIC, Australia.
Journal:J Neurol. 2023 Jun;270(6):2857-2889. doi: 10.1007/s00415-022-11545-6. Epub 2023 Jan 27.

24:Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases.
Authors:Abd-Nikfarjam B, Dolati-Somarin A, Baradaran Rahimi V, Askari VR
Institution:Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal:Biofactors. 2023 May-Jun;49(3):560-583. doi: 10.1002/biof.1936. Epub 2023 Jan 13.

25:Are movement-based mindful exercises (QIGONG, TAI CHI, AND YOGA) beneficial for stroke and Parkinson's disease? A scoping review.
Authors:García-Muñoz C, González-García P, Casuso-Holgado MJ, Martínez-Calderón J, Heredia-Rizo AM
Institution:Departamento de Enfermeria y Fisioterapia, Facultad de Enfermeria y Fisioterapia, Universidad de Cadiz, Avda. Ana de Viya 52, 11009 Cadiz, Spain; Uncertainty, Mindfulness, Self, Spirituality (UMSS) Research Group, Universidad de Sevilla, Sevilla, Spain.; Departamento de Fisioterapia, Facultad de Enfermeria, Fisioterapia y Podologia, Universidad de Sevilla, c/ Avicena s/n, 41009 Sevilla, Spain; Uncertainty, Mindfulness, Self, Spirituality (UMSS) Research Group, Universidad de Sevilla, Sevilla, Spain.
Journal:Complement Ther Med. 2023 Mar;72:102912. doi: 10.1016/j.ctim.2022.102912. Epub 2022 Dec 21.

26:Comparative efficacy and safety of monoamine oxidase type B inhibitors plus channel blockers and monoamine oxidase type B inhibitors as adjuvant therapy to levodopa in the treatment of Parkinson's disease: a network meta-analysis of randomized controlled trials.
Authors:Yan R, Cai H, Cui Y, Su D, Cai G, Lin F, Feng T
Institution:Department of Neurology, Center for Movement Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Journal:Eur J Neurol. 2023 Apr;30(4):1118-1134. doi: 10.1111/ene.15651. Epub 2022 Dec 11.

27:Efficacy of short pulse and conventional deep brain stimulation in Parkinson's disease: a systematic review and meta-analysis.
Authors:Zou X, Shi Y, Wu X, Ye Q, Lin F, Cai G
Institution:Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, 35001, China.
Journal:Neurol Sci. 2023 Mar;44(3):815-825. doi: 10.1007/s10072-022-06484-z. Epub 2022 Nov 16.

28:Efficacy and safety of non-ergot dopamine-receptor agonists as an adjunct to levodopa in advanced Parkinson's disease: A network meta-analysis.
Authors:Chen XT, Zhang Q, Wen SY, Chen FF, Zhou CQ
Institution:Department of Neurology, Bishan Hospital of Chongqing Medical University, Chongqing, China.
Journal:Eur J Neurol. 2023 Mar;30(3):762-773. doi: 10.1111/ene.15635. Epub 2022 Nov 30.

29:Swallowing outcomes in dysphagia interventions in Parkinson's disease: a scoping review.
Authors:Hirschwald J, Hofacker J, Duncan S, Walshe M
Institution:Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland; Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland.
Journal:BMJ Evid Based Med. 2023 Apr;28(2):111-118. doi: 10.1136/bmjebm-2022-112082. Epub 2022 Nov 11.

30:Rehabilitation Interventions for Improving Balance in Parkinson's Disease: A Narrative Review.
Authors:Lena F, Modugno N, Greco G, Torre M, Cesarano S, Santilli M, Abdullahi A, Giovannico G, Etoom M
Institution:From the Department of Neurology, IRCCS INM Neuromed, Pozzilli, Italy (FL, NM, MS); Consorzio San Stef. Ar. Abruzzo, Pescara, Italy (G. Greco, MT, SC); Department of Physiotherapy, Bayero University, Kano, Nigeria (AA); Dipartimento di Medicina e Scienze del Benessere, Universita degli Studi del Molise, Campobasso, Italy (G. Giovannico); and Physical Therapy Division-Allied Medical Sciences Department, Aqaba University of Technology, Aqaba, Jordan (ME).
Journal:Am J Phys Med Rehabil. 2023 Mar 1;102(3):270-274. doi: 10.1097/PHM.0000000000002077. Epub 2022 Jul 24.

31:Sexual Dysfunction in Parkinson's Disease: A Systematic Review of the Arizona Sexual Experience Scale Sexual Dysfunction in Parkinson Disease: A Systematic Review of the Arizona Sexual Experience Scale.
Authors:Benigno MDS, Amaral Domingues C, Araujo Leite MA
Institution:Neurology Department, 28110Federal Fluminense University, Niteroi, Brazil.
Journal:J Geriatr Psychiatry Neurol. 2023 Mar;36(2):87-97. doi: 10.1177/08919887221106424. Epub 2022 Jun 2.

32:Unmet needs in the diagnosis and treatment of Parkinson's disease psychosis and dementia-related psychosis.
Authors:Sabbagh M, Small GW, Isaacson SH, Torres-Yaghi Y, Pagan F, Pahwa R
Institution:Dignity Health/St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Journal:Int J Psychiatry Clin Pract. 2023 Mar;27(1):69-81. doi: 10.1080/13651501.2022.2058406. Epub 2022 May 14.

33:Deep Brain Stimulation in Parkinson Disease: A Meta-analysis of the Long-term Neuropsychological Outcomes.
Authors:Bucur M, Papagno C
Institution:Center for Mind/Brain Sciences (CIMeC), University of Trento, Trento, Italy.
Journal:Neuropsychol Rev. 2023 Jun;33(2):307-346. doi: 10.1007/s11065-022-09540-9. Epub 2022 Mar 23.

34:Gamma Knife® stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience.
Authors:Pérez-Sánchez JR, Martínez-Álvarez R, Martínez Moreno NE, Torres Diaz C, Rey G, Pareés I, Del Barrio A A, Álvarez-Linera J, Kurtis MM
Institution:Unidad de Trastornos del Movimiento, Servicio de Neurologia, Hospital Ruber Internacional, Madrid, Spain. Electronic address:
Journal:Neurologia (Engl Ed). 2023 Apr;38(3):188-196. doi: 10.1016/j.nrleng.2020.05.025. Epub 2022 Mar 16.

35:Salivation in Parkinson's disease: A scoping review.
Authors:Verhoeff MC, Koutris M, Vries R, Berendse HW, Dijk KDV, Lobbezoo F
Institution:Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal:Gerodontology. 2023 Mar;40(1):26-38. doi: 10.1111/ger.12628. Epub 2022 Mar 4.

36:Opicapone for the treatment of Parkinson's disease: a review.
Authors:Feldman M, Margolesky J
Institution:Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Journal:Int J Neurosci. 2023 May;133(5):532-543. doi: 10.1080/00207454.2021.1929217. Epub 2021 Jun 1.

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